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Application of polyferose in preparation of hyperphosphatemia treatment drug

A technology of hyperphosphatemia and polysaccharide iron, applied in the application field of medicine, can solve the problems of obvious phosphorus reduction effect, elevated serum calcium level, and deterring patients

Pending Publication Date: 2019-02-15
SHANGHAI PHARMA GRP QINGDAO GROWFUL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Calcium-containing phosphate binders are still used clinically, but long-term use can lead to elevated serum calcium levels, vascular calcification and other symptoms of hypercalcemia
The new phosphorus binders are mainly based on lanthanum carbonate, which has obvious phosphorus reduction effect and few side effects, but is expensive. For patients who are overwhelmed, even though they have more advantages than traditional phosphorus binders, they are still prohibitive for patients

Method used

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  • Application of polyferose in preparation of hyperphosphatemia treatment drug
  • Application of polyferose in preparation of hyperphosphatemia treatment drug
  • Application of polyferose in preparation of hyperphosphatemia treatment drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1 Preparation method of polysaccharide complex of the present invention

[0037] The syrup is made of starch, which is decomposed by amylase and glucoamylase into a mixture of glucose and polysaccharide, with a DE value of 80, a solid content of 26%, and a pH of 4.5;

[0038] A. At 6°C, use an interlayer glass-lined reaction tank, add 1110g of 32% concentration of ferric chloride hexahydrate aqueous solution and 775g of 25% concentration of syrup in the reaction tank, stir for 25 minutes, after stirring, within 85 minutes The sodium carbonate aqueous solution of 1000g20% concentration is added in the retort, and the control reaction temperature is 6 ℃, and after adding, continue to stir for 25 minutes, after stirring, the reaction solution is raised to room temperature, and now the reaction solution changes from strong acidity to acidity;

[0039] B. After rising to room temperature, add 625g of 20% aqueous sodium hydroxide solution, heat up to 60°C, and stir...

Embodiment 2

[0042] Embodiment 2 Preparation method of polysaccharide complex of the present invention

[0043] The syrup is purchased from starch, which is converted into a mixture of glucose and polysaccharides by enzymatic decomposition. The DE value is 75, the solid content is 25%, and the pH is 4;

[0044] A. At 4°C, use a laminated glass-lined reaction tank with a circulating cooling and heating device, add 1200g of 29% concentration of ferric chloride hexahydrate aqueous solution and 760g of 22% concentration of syrup in the reaction tank, stir for 20 minutes, and complete the stirring Finally, within 65 minutes, the sodium carbonate aqueous solution of 725g20% concentration is added in the retort, and the control reaction temperature is 4 ℃, and after adding, continue to stir for 20 minutes, after stirring, the reaction solution is warmed up to room temperature, at this moment, the reaction solution from strongly acidic to acidic;

[0045] B. After rising to room temperature, add ...

Embodiment 3

[0048] Embodiment 3 preparation method of polysaccharide complex of the present invention

[0049] The syrup is purchased from starch, which is converted into a mixture of glucose and polysaccharides by enzymatic decomposition. The index is DE value of 90, solid content of 30%, pH: 4.9;

[0050] A. At 8°C, use an interlayer titanium reaction tank, add 1110g of 35% concentration of ferric chloride hexahydrate aqueous solution and 790g of 28% concentration of syrup in the reaction tank, stir for 28 minutes, after the stirring is completed, within 70 minutes, add the The sodium carbonate aqueous solution of 960g20% concentration is added in the retort, and the control reaction temperature is 8 ℃, and after adding, continue stirring for 30 minutes, after stirring, the reaction solution is raised to room temperature, and now the solution changes from strongly acidic to acidic;

[0051] B. After rising to room temperature, add 650g of 20% aqueous sodium hydroxide solution, raise the...

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Abstract

The invention discloses an application of polyferose in preparation of a phosphate reduction drug. The phosphate reduction drug refers to a hyperphosphatemia treatment drug and is a phosphate adsorbent. The phosphate binding rate of polyferose is remarkably different from that of compound aluminium hydroxide tablets, calcium carbonate D3 tablets and lanthanum carbonate chewable tablets, that is, Pis lower than 0.01, and it indicates that the phosphate reduction effect of polyferose is better than that of the compound aluminium hydroxide tablets, the calcium carbonate D3 tablets and the lanthanum carbonate chewable tablets under the same dosage.

Description

technical field [0001] The invention relates to a new application of polysaccharide iron, in particular, the invention relates to the application of polysaccharide iron in the preparation of medicine for treating hyperphosphatemia. Background technique [0002] Phosphorus is a basic substance of the human body. It participates in the formation of fat, protein, and cell membranes. It is the basic component of the energy phosphate complex, accounting for about 1% of the body weight. The adult body contains about 600-900g, of which 85.7% is concentrated in bones and teeth. Under normal circumstances, the phosphorus in the human body is in a relatively stable state, and the phosphorus in the plasma fluctuates between 2.5-4.5mg / dL (0.81-1.45mmol / L). [0003] When the human body takes in excess phosphorus, it is very likely that osteoporosis and fragility, tooth decay, obvious calcium deficiency, listlessness, and even hyperphosphatemia may occur. When the human body lacks phosp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/26A61K31/715A61P3/12C08B37/00
CPCA61K31/715A61K33/26A61P3/12C08B37/00A61K2300/00
Inventor 仇立志王京端展筱林卢伟伸王冬
Owner SHANGHAI PHARMA GRP QINGDAO GROWFUL PHARMA CO LTD
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