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Centella asiatica extract applied to cosmetics and preparation method of centella asiatica extract

A technology of centella asiatica extract and cosmetics, which is applied in the direction of cosmetic preparations, cosmetics, dressing preparations, etc., which can solve the problems of complex plant components and limited separation efficiency of macroporous resins, and achieve good separation effects and reduce environmental pollution. Pollution pressure, effect of fewer processes

Active Publication Date: 2019-02-15
ZIGONG INNOVATION CENT OF ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limited separation efficiency of the macroporous resin and the complex plant components, the final Centella asiatica extract contains a large number of invalid components

Method used

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  • Centella asiatica extract applied to cosmetics and preparation method of centella asiatica extract
  • Centella asiatica extract applied to cosmetics and preparation method of centella asiatica extract
  • Centella asiatica extract applied to cosmetics and preparation method of centella asiatica extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: the preparation method of Centella asiatica extract

[0030] A centella asiatica extract used in cosmetics and a preparation method thereof, the steps are as follows:

[0031] Grind 10 kg of dried Centella asiatica into 50-mesh powder and put it into an extraction tank, add 100 L of 70% ethanol for the first extraction, let it soak for 5 hours, and filter; extract the residue for the second time, and add 100 L of 70% ethanol again % ethanol, let stand to soak for 5 hours, and filter; extract the residue for the third time, add 100L of 30% ethanol, let stand to soak for 5 hours, filter, and combine the three filtrates.

[0032] Concentrate the filtrate to a thick paste (4.4kg), add distilled water to disperse at a mass ratio of 1:1, and obtain Centella asiatica concentrate.

[0033] The concentrated solution was extracted 5 times with an equal volume of petroleum ether, each time standing for 1 hour, and the petroleum ether was recovered under reduced pres...

Embodiment 2

[0036] Embodiment 2: the preparation method of Centella asiatica extract

[0037] A centella asiatica extract used in cosmetics and a preparation method thereof, the steps are as follows:

[0038] Grind 4.5kg of dried whole centella asiatica into 50 mesh powder and put it into the extraction tank, add 22.5L of 30% ethanol for the first extraction, heat and reflux at 80°C for 30min, and filter; extract the residue for the second time, and add 22.5L of 30% ethanol, heated to reflux at 80°C for 30min, filtered; the residue was extracted for the third time, added 22.5L of 30% ethanol, left to soak for 30min, filtered, and the three filtrates were combined.

[0039] Concentrate the filtrate to a thick paste (1.85kg), add distilled water to disperse at a mass ratio of 1:1, and obtain Centella asiatica concentrate.

[0040] The concentrated solution was extracted 4 times with 2.7L of petroleum ether, each time standing for 40 minutes, the petroleum ether was recovered under reduced ...

Embodiment 3

[0043] Embodiment 3: the preparation method of Centella asiatica extract

[0044] A centella asiatica extract used in cosmetics and a preparation method thereof, the steps are as follows:

[0045] Grind 5 kg of dried Centella asiatica into 50-mesh powder and put it into an extraction tank, add 100 L of 80% ethanol for the first extraction, heat and reflux at 60°C for 2 hours, and filter; extract the residue for the second time, and add 100 L of ethanol again 80% ethanol, heated to reflux at 60°C for 2h, filtered; the residue was extracted for the third time, added 100L of 80% ethanol, left to soak for 2h, filtered, and the three filtrates were combined.

[0046] Concentrate the filtrate to a thick paste (1.4kg), add distilled water to disperse at a mass ratio of 1:1, and obtain Centella asiatica concentrate.

[0047] The concentrated solution was extracted 4 times with 2.8L of petroleum ether, each time standing for 0.5h, and the petroleum ether was recovered under reduced pr...

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Abstract

The invention discloses a centella asiatica extract applied to cosmetics and a preparation method of the centella asiatica extract. The preparation method comprises steps as follows: 1, dry all grassof centella asiatica is taken, smashed and mixed with an ethanol solution, a mixture is subjected to reflux heating and filtered, and a filtrate is collected; 2, the filtrate is concentrated to be pasty, water is added, and a centella asiatica concentrated solution is obtained; 3, the centella asiatica concentrated solution is extracted with petroleum ether, petroleum ether is recovered under reduced pressure in vacuum, and a petroleum ether spot sample is obtained; 4, the remaining concentrated solution is extracted with ethyl acetate, ethyl acetate is recovered under reduced pressure, and anethyl acetate spot sample is obtained; 5, the ethyl acetate spot sample is subjected to silica gel column adsorption and is eluted by mixed solvents in volume ratios of petroleum ether to acetone being 5:1 and 4:1 and then eluted by a mixed solvent with a volume ratio of petroleum ether to acetone being 2:1, the elution solvent with the volume ratio of petroleum ether to acetone being 2:1 is collected and is volatilized to be dry under reduced pressure, and a target sample is collected; 6, the target sample is subjected to vacuum drying, and the centella asiatica extract is obtained. The separation effect is good, the organic solvent is recycled, and the environmental pollution pressure is reduced.

Description

technical field [0001] The invention relates to a preparation method of plant extraction, in particular to a centella asiatica extract used in cosmetics and a preparation method thereof. Background technique [0002] Centella asiatica (Centella asiatica (L.) Urban) is the dried whole herb of Umbelliferae plant Centella asiatica (L.) Urban. It is widely distributed in the south of the Yangtze River Basin. The whole herb is used as medicine and can be harvested all the year round. It has been used in the field for thousands of years. It was first recorded in "Shen Nong's Materia Medica", listed as a middle grade, cold in nature, bitter in taste, and pungent. , heat stroke diarrhea, carbuncle sores, bruises, etc. The chemical constituents in Centella asiatica include triterpene saponins, triterpene acids, polyacetylenes and volatile oils. Modern studies have proved that Centella asiatica extract can effectively promote skin damage, local collagen synthesis and metabolism, and...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61Q19/02
CPCA61K2800/805A61Q19/02A61K8/9789
Inventor 朱云程汝滨汤丹
Owner ZIGONG INNOVATION CENT OF ZHEJIANG UNIV
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