A targeting fragment targeting 3 tissue factors

Abstract

The invention relates to targeted therapy with TF as the target, and provides four kinds of TF targeting fragments. The amino acid composition and base sequence of the four targeting fragments have been given, and the affinity of the four targeting fragments to TF was compared. These four targeting fragments can be used to construct TF-targeted drugs, and can also be directly used in TF-targeted therapy, and have therapeutic effects on various tumors expressing TF, tumor thrombus and other diseases.

Description

technical field [0001] The present invention relates to the field of targeted tumor therapy, in particular to a targeted therapy targeting tissue factor (TF). Background technique [0002] Targeting fragments are key elements in the construction of targeted drugs. An ideal targeting fragment needs to meet the following basic conditions: (1) It has a high binding ability to the target; (2) It will not trigger unwanted cascade reactions after binding to the target; (3) Most of the targeting fragments are small molecules Compound, easy to insert, digest and modify in genetic engineering. Molecules commonly used as targeting fragments include: (1) monoclonal antibodies; (2) natural ligands of receptors; (3) high-affinity targeting fragments screened by phage display technology or other methods. [0003] Phage display technology is a method that can screen out protein-specific high-affinity ligands, and is widely used in the screening of targeted fragments of targeted drugs. I...

AI Technical Summary

Problems solved by technology

This TF targeting fragment has high affinity with TF and does not cause blood coagulation and bleeding reactions, but has a large molecular weight and low stability

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