Method for extracting draba nemorosa amine B and draba nemorosa amine C from north semen lepidii as well as application thereof

A technology of Tinglizi and Tingliamine, which is applied in the field of medicine, can solve problems such as no public reports, and achieve remarkable economic and social benefits, scientific preparation methods, and abundant raw materials

Pending Publication Date: 2019-01-18
HENAN UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] With the research on the effective active ingredients and medicinal value of Tinglizi, it contains many medicinal active ingredients, including Tingliamine B and Tingliamine C, but how to extract them from Tinglizi and what are their properties Such efficacy has not been reported publicly so far

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  • Method for extracting draba nemorosa amine B and draba nemorosa amine C from north semen lepidii as well as application thereof
  • Method for extracting draba nemorosa amine B and draba nemorosa amine C from north semen lepidii as well as application thereof
  • Method for extracting draba nemorosa amine B and draba nemorosa amine C from north semen lepidii as well as application thereof

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Embodiment Construction

[0012] The specific implementation of the present invention will be described in detail below in combination with specific situations.

[0013] In the specific implementation of the present invention, a kind of Tingliamine B and Tingliamine C extracted from Tinglizi chinensis, the molecular structure formula is shown in figure 1 As shown, the preparation method is to take 10kg of Tinglizi, fry at 240°C for 5.5min, after frying, add 10 times the weight of Tinglizi to decoct and extract three times, each time for 1.5h, and combine three times The extract is concentrated under reduced pressure to an extract that is equivalent to 2g / ml of crude drug (ie 5L of extract). Pour out the supernatant, add 25L of ethanol with a volume concentration of 80% again for alcohol precipitation, and repeat the operation 4 times to combine the supernatant, concentrate until it has no alcohol smell, put it on a Dianion HP-20 column, and successively use water, volume concentration 20%, 40 %, 60% e...

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Abstract

The invention relates to a method for extracting draba nemorosa amine B and draba nemorosa amine C from north semen lepidii as well as application thereof. Draba nemorosa amine B and draba nemorosa amine C extracted by virtue of the method disclosed by the invention are used as exclusive active ingredients, an effect of reducing the activity of lipopolysaccharide-induced H9c2 cells can be achieved, draba nemorosa amine B and draba nemorosa amine C are effectively used for preparing a drug for protecting myocardium. The method disclosed by the invention has the advantages of rich raw materials,scientific preparation method, easiness in operation, capability of effectively extracting draba nemorosa amine B and draba nemorosa amine C from north semen lipidii, capability of increasing the medicinal value and commercial value of north semen lipidii, and significant economic and social benefits.

Description

technical field [0001] The invention relates to medicine, in particular to a method for extracting Tingliamine B and Tingliamine C from Tinglizi [0002] law and its application. Background technique [0003] Tinglizi is a commonly used Chinese herbal medicine. It was first recorded in "Shen Nong's Materia Medica", and it was listed as a herbal inferior product. The medicine tastes pungent and bitter, and is very cold in nature. The "Tinglizi" included in the 2015 edition of "Chinese Pharmacopoeia" has a north-south distinction. Among them, the dry mature seeds of the cruciferous plant Lepidium apetalum Willd. .) The dry and mature seeds of Webbex Prantl. are commonly called "Nan Tinglizi". The active ingredients and medicinal value of the two Tinglizi are not completely the same, and there are substantial differences. [0004] With the research on the effective active ingredients and medicinal value of Tinglizi, it contains many medicinal active ingredients, including Tin...

Claims

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Application Information

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IPC IPC(8): C07C231/24C07C237/22A61K31/198A61P9/00
CPCC07C231/24A61K31/198A61P9/00C07C237/22
Inventor 李孟曾梦楠张靖柯张志广吕锦锦石静亚冯卫生郑晓珂
Owner HENAN UNIV OF CHINESE MEDICINE
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