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Application of pattern recognition receptor TREM2 in liver cancer prognosis and treatment

A liver cancer, prognosis technology, applied in the field of biomedicine

Inactive Publication Date: 2019-01-01
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At this stage, there are few studies on the expression changes and functional activities of TREM2 in malignant tumors. We are committed to studying the functional activities of TREM2 in liver cancer and the specific mechanism of regulating liver cancer, hoping to use it as a new target for precise treatment of liver cancer. Provides new avenues for immunological treatments

Method used

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  • Application of pattern recognition receptor TREM2 in liver cancer prognosis and treatment
  • Application of pattern recognition receptor TREM2 in liver cancer prognosis and treatment
  • Application of pattern recognition receptor TREM2 in liver cancer prognosis and treatment

Examples

Experimental program
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Effect test

Embodiment 1

[0041] Example 1. Detection of TREM2 receptor mRNA expression level in liver cancer tissues of patients with liver cancer by real-time fluorescent quantitative PCR method

[0042] The purpose of this example is to prove that the expression level of TREM2 receptor mRNA in liver cancer tissues of patients with liver cancer is significantly lower than the expression level of TREM2 receptor mRNA in paracancerous tissues.

[0043] In this example, the liver cancer tissues were obtained from 50 patients randomly generated from 1672 cases of hepatocellular carcinoma resection at the Department of Liver Tumor Surgery, Zhongshan Hospital, Fudan University Affiliated to Zhongshan Hospital between January 2008 and December 2009. . Inclusion criteria: (1) Hepatocellular carcinoma was clearly diagnosed by pathology; (2) No distant metastasis was found in imaging; (3) The operation was the first radical liver resection; (4) No targeted drugs were received before the operation , interventio...

Embodiment 2

[0045] Example 2. Detecting the Expression Level of TREM2 Receptor in Liver Cancer Tissues of Liver Cancer Patients by Immunohistochemical Method

[0046] The purpose of this example is to prove that the expression level of TREM2 receptor in liver cancer tissues of patients with liver cancer is significantly lower than that in paracancerous tissues.

[0047] In this example, the liver cancer tissues were obtained from 250 randomly generated cases among the 1672 cases of hepatocellular carcinoma resection in the Department of Liver Tumor Surgery, Zhongshan Hospital Affiliated to Fudan University between January 2008 and December 2009, which met the following inclusion criteria patient. The inclusion criteria are the same as in Example 1. All patients will be followed up with the operation time as the starting point, and will be reexamined every 3 months within 1 year after surgery, every six months in the second year, and once a year in the 3rd to 5th years. Markers (AFP, etc...

Embodiment 3

[0048] Example 3. Using Survival Analysis to Evaluate the Impact of TREM2 on the Prognosis of Liver Cancer Patients

[0049] The purpose of this example is to prove that the expression level of TREM2 in liver cancer tissues of patients with liver cancer is related to the prognosis of liver cancer.

[0050] In this example, the research cohort was as described in Example 2, and the Kaplan-Meier method was used to draw the survival curve, and the log-rank test was used to compare between groups, so as to reveal the influence of TREM2 expression in cancer tissues of patients with liver cancer on the prognosis of patients. The correlation between the expression level of TREM2 and the prognosis of liver cancer is as follows: image 3 As shown, the low expression of TREM2 in liver cancer tissues is closely related to the poor prognosis of patients, and the overall survival time (P=0.0013) and tumor progression time (P=0.0006) of patients with low TREM2 expression were significantly ...

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Abstract

The invention discloses application of a pattern recognition receptor TREM2 in liver cancer prognosis and treatment, and particularly discloses a biomarker used for predicting liver cancer existence and relapse for patients affected with liver cancer, and application of the TREM2 as a novel target in liver cancer targeted treatment. Researches show that expression of the TREM2 is obviously reducedin liver cancer tissue, and is significantly lower than that in normal tissue; low expression of the TREM2 in liver cancer tissue is closely related to poor prognosis of patients; the total survivaltime and the tumor progression time of a patient with low TREM2 expression are shorter than those of patients with high expression; and after activation and overexpression of the TREM2 in MHCC97H cells, proliferation capability of liver cancer cells is significantly suppressed. Accordingly, the TREM2 can be adopted as the biomarker for prognosis of patients with liver cancer, and can predict the survival time of patients with liver cancer and the risk of relapse, and the TREM2 can be adopted as a novel treatment target to perform individualized precise intervention treatment according to the level of the receptor TREM2 of patients.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of pattern recognition receptor TREM2 in the prognosis and treatment of liver cancer. Background technique [0002] Hepatocellular carcinoma (HCC) is the fifth most common malignant tumor in the world, ranking the second and sixth among the leading causes of cancer death in men and women. There are more than 620,000 new cases of HCC worldwide each year. The onset of liver cancer is insidious and the prognosis is poor. Most of them are in the middle and late stage when they see a doctor, and there is a lack of effective radical treatment. Since sorafenib was approved for the first-line treatment of advanced liver cancer in 2007, targeted therapy drugs have brought new hope to patients with advanced liver cancer. However, so far, there are still many problems to be solved, such as sorafenib can only prolong the median survival time of advanced liver cancer by ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886G01N33/574A61K45/00A61P35/00
CPCA61K45/00A61P35/00C12Q1/6886C12Q2600/118C12Q2600/158G01N33/57438G01N2800/52
Inventor 夏景林张思杨毕伟唐文清苑菲菲郭梦舟
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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