Biological glue for promoting local hemostasis of postoperative wounds and promoting epithelization of postoperative wounds, and working method thereof

Abstract

The invention discloses a biological glue for promoting local hemostasis of postoperative wounds and promoting epithelization of the postoperative wounds. The biological glue comprises a reagent A anda reagent B, the reagent A comprises prothrombin and a calcium chloride solution, and the reagent B comprises fibrinogen, recombinant human epidermal growth factor and glycerol. The biological glue has the local hemostasis and transplanted flap and surgical wound bonding effects, and also can well promote the epithelialization of the surgical wounds; the glue is soft, has good compatibility withthe human body, and can well overcome wound swelling pains caused by the gauze packing operation and greatly reduce the postoperative discomfort of patients; and components contained in the glue are harmless to the human body and can be absorbed by the human body, so the patient can leave the hospital after surgery without cleaning the remaining glue, the patient's length of stay is significantlyshortened, and the patient's economic pressure is reduced.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a bioglue and a preparation method thereof, in particular to a bioglue for promoting local hemostasis of postoperative wounds and epithelialization of postoperative wounds and a working method thereof. Background technique [0002] For patients with simple nasopharyngeal residual or recurrent nasopharyngeal carcinoma after radiotherapy, surgical treatment can directly remove radiotherapy-insensitive lesions and avoid radiation damage. It is a better choice for patients with local failure of nasopharyngeal carcinoma after radiotherapy. Surgery is the only effective treatment for nasopharyngeal necrosis after radiotherapy for nasopharyngeal carcinoma. However, due to radiotherapy, the healing ability of the nasopharynx is reduced, and epithelial regeneration is affected. Some patients often have wounds that cannot be effectively epithelialized after surgery, and some even progress to necros...

AI Technical Summary

Problems solved by technology

[0003] As early as 2009, the applicant created an innovative repair technique - nasal mucoperiosteal flap repair with vascular pedicles. This technique can effectively promote the epithelialization of the wound, but it usually takes 2-3 months to complete after surgery. Thorough epithelialization of surgical wounds; the nasopharynx is located at the bottom of the middle cranial fossa, deep and narrow, and the operating space is extremely limited. Sutures cannot be performed after flap transplantation. Before the flap is anastomosed with the surrounding tissue, there is an If the gauze is not tight or even falls, the gauze needs to be stuffed to prevent the flap from shifting, but it takes a week for the technique to remove the gauze. In addition, the tight packing may cause avascular necrosis of the mucoperiosteal flap. After the gauze is pulled out, it may also be caused by The patient's severe cough caused the flap to fall due to gravity, resulting in failure of the repair

[0004] "Biological glue" was originally a method newly invented by American researchers. It has the function of promoting local hemostasis of the wound, and the glue is usually relatively soft and does not cause discomfort, but the existing biological glue does not have the ability to promote wound epithelialization function of

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