Transurethral Bladder Access Device

Abstract

The present invention is a transurethral bladder communication device, which is characterized in that the communication body includes a buffer chamber and a drug administration chamber, the top of the buffer chamber is connected to the animal catheter, and the bottom end is provided with a buffer chamber sealing rubber plug. A central hole is provided in the buffer chamber plugging rubber plug, the annular wall of the buffer chamber is connected to the bottom end of the connection port, the top end of the connection port is sealed to one end of the drug delivery tube, and the other end is sealed to the top end of the drug delivery chamber. The bottom end of the drug delivery cavity is provided with a drug delivery cavity seal, the inner core includes a metal inner core, a base and a handle, the base is connected and fixed to the handle, the base is provided with a through hole, and the bottom of the metal inner core The end is inserted and fixed in the through hole. The invention provides a minimally invasive communication device for infusing the bladder of experimental animals with medicinal liquid and subsequent laser irradiation treatment through the urethra, so as to achieve the purpose of safety, effectiveness and minimal invasiveness.

Description

technical field [0001] The invention relates to a transurethral bladder communication device, which is an experimental device for basic research on animal bladder. Background technique [0002] At present, for the research of bladder diseases, researchers often conduct experiments and studies by establishing animal models of corresponding diseases. During the experiment, drugs and cells and other biological agents need to be injected into the bladder of animals to observe the formation and development of inflammation and tumors in the bladder. For the treatment of related diseases with drugs, the research on biomaterials has accelerated the development of auxiliary experimental equipment. Most biomaterials, especially nanomaterials, can only exert their biological effects under laser irradiation. The principle is that they have photothermal properties. After the drug is activated by the laser, it produces a photodynamic reaction to produce highly active singlet oxygen. The s...

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Problems solved by technology

[0002] At present, for the research of bladder diseases, researchers often conduct experiments and studies by establishing animal models of corresponding diseases. During the experiment, drugs and cells and other biological agents need to be injected into the bladder of animals to observe the formation and development of inflammation and tumors in the bladder. For the treatment of related diseases with drugs, the research on biomaterials has accelerated the development of auxiliary experimental equipment. Most biomaterials, especially nanomaterials, can only exert their biological effects under laser irradiation. The principle is that they have photothermal properties. After the drug is activated by the laser, it produces a photodynamic reaction to produce highly active singlet oxygen. The singlet oxygen undergoes an oxidation reaction with adjacent biomacromolecules, resulting in oxidative toxicity, which in turn leads to damage or even death of bacteria or cells. Adjacent tissues are not affected in any way, but the penetration of near-infrared laser tissue has certain limitations (penetration distance 8mm), so most materials can only be applied to body surface diseases, such as skin diseases, skin tumors, etc., which greatly limits According to its experimental and applied research, the bladder has natural anatomical advantages because it directly communicates with the outside world through the urethra. Clinically, the bladder can be infused with drugs through the urethra and treated with laser irradiation to stimulate biological properties and achieve the purpose of treatment. There is not yet a minimally invasive urethra-only device used for drug infusion in the bladder of experimental animals and a communication device for laser irradiation therapy

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