Blood cell pulse identification method and identification device based on the principle of sheath flow impedance

Abstract

The invention relates to a blood cell pulse identification method based on the principle of sheath flow impedance, which includes the steps of: 1) determining the slope edge of the pulse signal; 2) finding the trough and peak, and recording the abscissa a corresponding to the trough, and the The abscissa b, records the relative height of the pulse signal Δh = f(b)-f(a); 3) Find the abscissa c corresponding to the pulse end point, the height of the pulse end point is f(c); 4) Obtain the wave peak and The number of intermediate valleys between the pulse end points is N. If N=0, record the second signal feature of the pulse signal; if N≥1, proceed to step 5); 5) Along the positive direction of the horizontal axis, measure the intermediate valleys closest to the peak. Record it as the starting point, obtain its abscissa d, record the third signal feature of the pulse signal, and return to step 1). This method is not only simpler and faster, but also the statistical results are more accurate and reliable. The invention also discloses a blood cell pulse identification device based on the sheath flow impedance principle.

Description

technical field [0001] The invention relates to the technical field of detection, in particular to a blood cell pulse identification method and identification device based on the principle of sheath flow impedance used in the field of medical detection. Background technique [0002] At present, most blood cell analyzers use the Coulter principle to detect cells. The so-called Coulter principle specifically refers to the electrical impedance principle. This principle is to make cells suspended in electrolyte pass through a small hole, and an electrode is immersed on both sides of the small hole. , when cells pass through a small hole, the resistance changes to generate voltage pulses. The pulse amplitude is usually proportional to the volume of cell particles. These pulses can be used to measure the distribution and quantity of cell volume after amplification and identification. [0003] According to the above principles, only the amplitude of the pulse signal generated when ...

AI Technical Summary

Problems solved by technology

Although this method alleviates the influence of "M wave" to a certain extent, the efficiency of the entire statistical process is very low because of the need to extract data features and then screen abnormal pulses; in addition, in this method, the "M wave" and "m It is necessary to add a variety of experience-related thresholds when classifying waves, and the selection of thresholds has a great impact on the results, which makes it impossible to guarantee the accuracy of signal processing using this method

Images