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Application of radix angelicae sinensis as unique active component to preparation of drugs for relieving fever

An active ingredient, the technology of angelica extract, is applied in the application of angelica as the only active ingredient in the preparation of antipyretic drugs, and in the field of prevention and treatment of infectious fever, which can solve the problems that have not been applied and achieve significant curative effect

Pending Publication Date: 2018-11-23
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the treatment of fever, it often appears in the form of compound prescriptions, but the medicine with angelica as a single effective medicinal ingredient has a significant curative effect in the prevention and treatment of fever, but it has not been applied.

Method used

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  • Application of radix angelicae sinensis as unique active component to preparation of drugs for relieving fever
  • Application of radix angelicae sinensis as unique active component to preparation of drugs for relieving fever

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take the medicinal material of Angelica sinensis, pulverize, pass through a 100-mesh sieve, pack separately, and prepare into powder.

Embodiment 2

[0020] Take angelica medicinal material, pulverize, add 8 times the amount of 70% ethanol, soak overnight, heat and reflux for extraction 3 times, combine the filtrate, recover alcohol, concentrate, dry, and measure the content of ligustilide and ferulic acid to 51.2%. was 1.3%. Then it is powdered and added with an appropriate amount of excipients such as dextrin, and compressed into tablets to prepare 0.5 g tablets.

Embodiment 3

[0022] Take angelica medicinal material, pulverize, add 8 times the amount of 10% ethanol, soak overnight, heat and reflux extraction 3 times, combine the filtrate, recover alcohol, concentrate, dry, and measure the content of ligustilide to 50.8%, and the mass content of ferulic acid 1.5%. Then powder it, add excipients such as an appropriate amount of dextrin, and pack into capsules to prepare 0.4 g capsules.

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PUM

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Abstract

The invnetion discloses application of radix angelicae sinensis as a unique active component to preparation of drug for relieving fever. The drug for relieving fever is obtained by taking the radix angelicae sinensis or a radix angelicae sinensis extract as the unique active component and adding acceptable auxiliary additive component. The radix angelicae sinensis extract can be an extract of theradix angelicae sinensis extracted with 0 to 100% ethanol solution or radix angelicae sinensis volatile oil, the mass content of ferulic acid in an ethanol extract is larger or equal to 1%, the mass content of ligustilide in the ethanol extract is larger than or equal to 30%, the mass content of ligustilide in the radix angelicae sinensis volatile oil is larger than or equal to 30%. the application of the radix angelicae sinensis as the unique active component to preparation of drug for relieving fever takes the radix angelicae sinensis or the radix angelicae sinensis extract as the unique active component, the prepared drug is applied to prevention and control of fever, achieves significant curative effects, for example, when the effective drug component is within a certain range, the effect of relieving the fever of the effective drug component is superior to that of aspirin and a ligustilide monomer.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, more specifically, the application of Angelica sinensis as the only active ingredient in the preparation of antipyretic drugs. The medicament for antipyretic diseases described in the present invention is suitable for the prevention and treatment of fever, especially for the prevention and treatment of infectious fever. Background technique [0002] Fever is commonly known as fever, with elevated body temperature as the main clinical manifestation. Refers to the situation in which pyrogens directly act on the thermoregulatory center, the dysfunction of the thermoregulatory center, or excessive heat production and reduced heat dissipation caused by various reasons, resulting in an increase in body temperature beyond the normal range. It is generally believed that when the oral temperature is higher than 37.5°C, the armpit temperature is higher than 37°C, or the difference in body tempe...

Claims

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Application Information

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IPC IPC(8): A61K36/232A61P29/00
CPCA61K36/232A61P29/00
Inventor 谭正怀熊静悦唐大轩刘琪张秀
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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