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Application of pharmaceutical composition in preparing antibacterial drugs

An antibacterial drug and composition technology, which is applied to the application field of pharmaceutical composition in the preparation of antibacterial drugs, can solve the problems of bacterial resistance and endanger human health, etc., and achieve the effects of good antibacterial effect, prolonging survival time and broad application prospect.

Active Publication Date: 2018-11-16
深圳市新鸿镁医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, in the process of treating bacterial infectious diseases, a large number of antibiotics, such as cephalosporins and penicillins, are used in large quantities. During their extensive use, bacterial resistance is caused, and more and more drug-resistant strains appear , seriously endangering human health

Method used

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  • Application of pharmaceutical composition in preparing antibacterial drugs
  • Application of pharmaceutical composition in preparing antibacterial drugs
  • Application of pharmaceutical composition in preparing antibacterial drugs

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preparation example Construction

[0032] Further, the preparation method of this pharmaceutical composition comprises:

[0033] Mixing and refluxing the mixed medicinal materials formed by Carotid fennel and Thorn bean and 70-100% ethanol solution according to a material-to-liquid ratio of 1:15-25 are extracted for 2-4 times, each time for 0.5-1.5 hours, and the obtained extract is concentrated and dried. Dry.

[0034] Preferably, the temperature of reflux extraction is 60-80°C, or 65-75°C, or 70°C.

[0035] Preferably, the solid-liquid ratio is 1:17-24, or 1:19-22, or 1:20.

[0036] Preferably, the concentration of the ethanol solution is 80-100%, or 90-100%, or 95%.

[0037] Preferably, the extraction is performed 2 to 3 times, and each time is 0.8 to 1.2 h; or the extraction is performed 3 times, and each time is 1 h.

[0038] This embodiment also provides a liquid preparation for treating bacterial infectious pneumonia, which is prepared by mixing the above-mentioned pharmaceutical composition with ster...

Embodiment 1

[0043] The present embodiment provides a pharmaceutical composition, which comprises fennel serrata and thorn bean in a mass ratio of 1:1.

[0044] The preparation method of this pharmaceutical composition comprises:

[0045] The fennel cuminata and the falciparum falciparum were mixed at a mass ratio of 1:1, and mixed with 95% ethanol at a material-to-liquid ratio of 1:20, and refluxed for extraction at 70° C. for 3 times, 1 hour each time. The supernatant is recovered, concentrated, dried, and pulverized to obtain it.

Embodiment 2

[0047] The present embodiment provides a pharmaceutical composition, which comprises fennel cuminata and thorn bean in a mass ratio of 1:5.

[0048] The preparation method of this pharmaceutical composition comprises:

[0049] The fennel cuminata and the falciparum falciparum were mixed at a mass ratio of 1:5, and mixed with anhydrous ethanol at a material-to-liquid ratio of 1:15, and were extracted twice at 80°C by refluxing for 1.5 hours each time. The supernatant is recovered, concentrated, dried, and pulverized to obtain it.

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Abstract

The invention provides application of a pharmaceutical composition in preparing antibacterial drugs, and belongs to the field of medicines. The pharmaceutical composition is an extract obtained by extracting hypecoum leptocarpum and oxytropis which are mixed in the mass ratio being 1:(0.2-5). The pharmaceutical composition can prolong the average survival time of mice subjected to bacterial infection, the fatality rate of bacterial infection is lowered, and the antibacterial effect is very good. Thus the pharmaceutical composition can be used for preparing the antibacterial drugs, and is particularly suitable for preparing drugs for treating infectious pneumonia, and the application prospect is wide.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of a pharmaceutical composition in the preparation of antibacterial drugs. Background technique [0002] Antibacterial drugs generally refer to drugs with bactericidal or bacteriostatic activity, including various antibiotics, sulfonamides, imidazoles, nitroimidazoles, quinolones and other chemically synthesized drugs. Certain products obtained by culturing microorganisms such as bacteria, actinomycetes and fungi, or the same or similar substances produced by chemical semi-synthesis, can also be chemically synthesized. Antibacterial drugs can inhibit and kill pathogens at a certain concentration. [0003] At present, in the process of treating bacterial infectious diseases, antibiotics, such as cephalosporins, penicillins, etc., are used in large quantities. , seriously endanger human health. In view of this, this patent is hereby proposed. SUMMARY OF THE INVENTION ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/66A61K9/72A61P31/04A61P11/00A61P31/10
CPCA61K9/007A61K36/48A61K36/66A61K2236/333A61K2236/39A61P11/00A61P31/04A61P31/10A61K2300/00
Inventor 陈行平陶燕铎江磊
Owner 深圳市新鸿镁医疗器械有限公司
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