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Method for preventing or treating solid tumors and blood system tumors and bear gall powder used in same

A technology of bear bile powder and bear bile, which is applied in the fields of cardiovascular system diseases, antineoplastic drugs, medical preparations containing active ingredients, etc., can solve the problems of limiting the application range of bear bile powder, many impurities, unstable properties, etc.

Inactive Publication Date: 2018-11-13
齐光伟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] CN1311002A (00102073.0, Shi Lixia) discloses a refined bear bile powder and its preparation method, which belongs to the field of pharmacy. Common bear bile powder is easy to absorb moisture and agglomerate, has a sticky tooth feeling, extremely fishy smell, extremely bitter taste, many impurities, and slow absorption. The property is unstable and easy to be corrupted, and the content of active ingredients is low, which limits the application range of bear bile powder. Oral application often adds flavoring agents to reduce the stench

Method used

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  • Method for preventing or treating solid tumors and blood system tumors and bear gall powder used in same
  • Method for preventing or treating solid tumors and blood system tumors and bear gall powder used in same
  • Method for preventing or treating solid tumors and blood system tumors and bear gall powder used in same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0100] Embodiment 1: prepare bear bile powder

[0101] (1) Filtrate the bear bile collected by the tubeless drainage method to obtain the filtrate, add 0.75 times the amount of water to dilute to obtain bear bile fluid, and place it at a temperature of 2-6°C for 12 hours before performing subsequent operations;

[0102] (2) In the mode of bubbling, in step (1) gained bear bile liquid, be charged with nitrogen for 27min, then be charged with carbon dioxide for 18min;

[0103] (3) Pour the bear bile liquid processed through the above operations into the material tray (the depth of the liquid layer is 1.5~2.5cm), and immediately place it in a freeze dryer that has been frozen to -50°C in advance, and freeze it for 3.5 hours; The temperature was raised to -22°C at a rate of 0.3°C and kept for 1 hour; then the temperature was raised to -3°C at a rate of 0.3°C per minute and kept for 2.5 hours; then the temperature was raised to 10°C at a rate of 0.3°C per minute and kept for 4.5 h...

Embodiment 2

[0111] Embodiment 2: prepare bear bile powder

[0112] (1) Filtrate the bear bile collected by the tubeless drainage method to obtain the filtrate, add 0.5 times the amount of water to dilute to obtain the bear bile fluid, and let it stand at a temperature of 2-6° C. for 12 hours before performing subsequent operations;

[0113] (2) In the mode of bubbling, in step (1) gained bear bile liquid, be filled with nitrogen 30min, then be filled with carbon dioxide 15min;

[0114] (3) Pour the bear bile liquid processed through the above operations into the material tray (the depth of the liquid layer is 1.5~2.5cm), and immediately place it in a freeze dryer that has been frozen to -55°C in advance, and freeze it for 3 hours; The temperature was raised to -23°C at a rate of 0.3°C and kept for 1.5 hours; then the temperature was raised to -2°C at a rate of 0.25°C per minute and kept for 2 hours; then the temperature was raised to 12°C at a rate of 0.25°C per minute and kept for 5 ho...

Embodiment 3

[0122] Embodiment 3: prepare bear bile powder

[0123] (1) Filter the bear bile collected by the tubeless drainage method to obtain the filtrate, add 1 times the amount of water to dilute to obtain the bear bile fluid, and let it stand at a temperature of 2-6°C for 12 hours before performing subsequent operations;

[0124] (2) In the mode of bubbling, in step (1) gained bear bile liquid, be filled with nitrogen 25min, then be filled with carbon dioxide 20min;

[0125] (3) Pour the bear bile liquid processed through the above operations into the material tray (the depth of the liquid layer is 1.5~2.5cm), and immediately place it in a freeze dryer that has been frozen to -45°C in advance, and freeze it for 4 hours; The temperature was raised to -20°C at a rate of 0.35°C and kept for 1.2 hours; then the temperature was raised to -2°C at a rate of 0.35°C per minute and kept for 3 hours; then the temperature was raised to 15°C at a rate of 0.34°C per minute and kept for 4 hours; ...

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Abstract

The invention discloses a method for preventing or treating solid tumors and blood system tumors and bear gall powder used in the same. The bear gall powder can be used for adjusting blood fat, reducing total cholesterol, preventing cardiovascular and cerebrovascular diseases, preventing atherosclerosis and treating or preventing the solid tumors and the blood system tumors. The invention discloses a preparation method of the bear gall powder and the bear gall powder obtained through the method. In a bear gall powder preparation process, a material is subjected to ice crystallization and thenfreeze drying, and the obtained freeze dried bear gall powder can be called ice crystal-state bear gall powder or ice crystal bear gall powder; especially, the bear gall powder which can be called senbao bear gall powder does not contain any auxiliaries or chemical additives; more especially, the invention finds that the ice crystal-state bear gall powder can not only more effectively adjust the blood fat and reduce the total cholesterol, but also more effectively be used for preventing the cardiovascular and cerebrovascular diseases, preventing atherosclerosis and the like, and more especially, the ice crystal-state bear gall powder can effectively be used for preventing and treating the solid tumors and blood system tumors.

Description

technical field [0001] The invention belongs to the technical field of medicine and health products, relates to a bear bile powder prepared by a specific process, and also relates to a preparation method of the bear bile powder. In the process of preparing the bear bile powder, the material is ice-crystallized and then freeze-dried, so that the prepared bear bile powder exhibits excellent technical effects, especially in terms of physical and chemical properties. In particular, the present invention pre-dilutes bear bile powder with a small amount of water, fills it with two kinds of gas, and carries out deep freezing, so that the active ingredients contained in bear bile are in a state of ice crystals, and then sublimated, so that the obtained freeze-dried Bear bile powder can be referred to as ice crystal bear bile powder in the present invention, or can be called ice crystal bear bile powder, or can be called Senbao bear bile powder. Especially the bear bile powder that th...

Claims

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Application Information

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IPC IPC(8): A61K35/413A61P3/06A61P9/10A61P9/00A61P35/00A23L33/00
CPCA61K35/413A23L33/00A23V2002/00A61P3/06A61P9/00A61P9/10A61P35/00A23V2200/326A23V2200/3262A23V2200/308A23V2250/204
Inventor 齐光伟
Owner 齐光伟
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