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Injected face filler compound gel for cosmetic plastic surgery and preparation method thereof

A filler and injection-type technology, which is applied in the field of injection-type facial filler composition gel for cosmetic plastic surgery and its preparation, can solve problems such as inability to fill, increased extrusion force, and short residence time of hyaluronic acid. Achieve the effect of easy clinical injection and improved durability

Inactive Publication Date: 2018-11-06
北京水元生生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The long-term safety of cross-linked hyaluronic acid residual cross-linkers is still a concern, however, a single hyaluronic acid has a short residence time in the body and requires repeated injections to maintain cosmetic effects
[0006] In addition, the above-mentioned injectable gel containing cross-linked hyaluronic acid and microparticles such as hydroxyapatite faces two main problems in industrial production: 1) In order to ensure that the injectable gel is free of air bubbles, it needs to be vacuum degassed and then infused. In the process of filling, it was found that the gel was dehydrated, and a two-phase region appeared, so it could not be filled; 2) In order to avoid the deposition of hydroxyapatite particles in its container over time, the dynamic viscosity of the gel was relatively high, which made the extrusion force larger , not easy for clinical injection, if the viscosity is reduced, hydroxyapatite deposits, and heterogeneous areas will appear at the injection site

Method used

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  • Injected face filler compound gel for cosmetic plastic surgery and preparation method thereof
  • Injected face filler compound gel for cosmetic plastic surgery and preparation method thereof
  • Injected face filler compound gel for cosmetic plastic surgery and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1 Preparation of a single gel composition (HP) with 1%, 2%, 4% hyaluronic acid and with 30% hydroxyapatite microparticles (comparative gels).

[0054] An HP gel composition with a sodium hyaluronate concentration of 1% was prepared.

[0055] Add 1 g of HA to 100.9 g of solution A under slow stirring, fully wet and swell, and let it stand for 6 hours to obtain a clear and transparent solution or gel. Then add 43.67g of hydroxyapatite and grind or stir for 10min to make it mix into a homogeneous phase.

[0056] According to the formula in Example 1 in Table 1, the formulation amounts of HA, hydroxyapatite and solution A were weighed, and the preparation method was the same as that of the HP gel composition with 1% sodium hyaluronate.

[0057] Table 1: The formula composition of embodiment 1,2,3

[0058]

Embodiment 2

[0059] Example 2 Preparation of a single gel composition (MP) with 1%, 3%, 5% methylcellulose (MC) and with 30% hydroxyapatite (CaHAP) microparticles (comparative gels).

[0060] The specific formula is shown in Table 1, Example 2, the preparation method is the same as that of the HP gel composition of 1% sodium hyaluronate in Example 1, and sodium hyaluronate is replaced by sodium methylcellulose in this example. Can.

Embodiment 3

[0061] Example 3 Preparation of a single gel composition (CP) with 2%, 4%, 6% carboxymethylcellulose sodium (CMC-Na) and with hydroxyapatite (CaHAP) microparticles (comparative gels)

[0062] The specific formula is shown in Table 1, Example 3, the preparation method is the same as that of the HP gel composition of 1% sodium hyaluronate in Example 1, and the sodium hyaluronate is replaced by the methyl cellulose in this example. .

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Abstract

The invention discloses an injected face filler compound gel for cosmetic plastic surgery and a preparation method thereof. The injected face filler compound gel is used for plastic surgery and is mainly contains gel formed by organically mixing non-crosslinking sodium hyaluronate and cellulose ethers and optional fine particles such as hydroxyapatite (CaHAP) fine particles. The injected face filler compound gel for cosmetic plastic surgery is uniform in texture, can stabilize the fine particles for a long time, for example, the hydroxyapatite uniformly dispersed in the gel, has expected rheological behavior (high elasticity modulus and high dynamic viscosity) and meanwhile is suitable for industrial filling and clinic injection.

Description

technical field [0001] The invention belongs to the technical field of cosmetic plastic surgery, and in particular relates to an injection-type facial filler composition gel for cosmetic plastic surgery and a preparation method thereof. Background technique [0002] Skin naturally loosens and wrinkles over time, especially facial contour aging, including visible skin lines, deep nasolabial folds, frown lines, marionette lines, buccal seam lines, mouth circumference wrinkles, temporal Collapse etc. Similarly, the collapse of the bridge of the nose due to congenital or trauma, as well as improper browbones and chins, etc. have brought troubles and pains to people. Beauty is an eternal topic and goal pursued by human beings. How to effectively delay skin aging and beautify the appearance is still a problem that people continue to explore and solve. [0003] Injection of facial fillers for aesthetic plastic surgery can effectively solve the above problems and support the colla...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/12A61L27/20
CPCA61L27/12A61L27/20A61L27/50A61L2400/06A61L2430/06C08L5/08C08L1/286C08L1/284C08L1/28C08L1/282
Inventor 高会乐药晓勤秦琳
Owner 北京水元生生物科技有限公司
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