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Photon metasurface biosensor

It is a biosensor and an extraordinary technology, which can be used in instruments, scientific instruments, and material analysis by optical means.

Inactive Publication Date: 2018-11-02
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing surface plasmon resonance biosensors generally use periodic gold or silver films on micro-nano fibers to achieve biological detection, but there are shortcomings such as weak micro-nano fibers and difficult coatings, and the accuracy of the size of the fibers is required higher

Method used

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Examples

Experimental program
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Embodiment 1

[0021] Firstly, the structure of the photonic metasurface biosensor based on local surface plasmon resonance is designed, and the thickness of the metal thin film layer, the thickness of the dielectric thin film layer, and the structural parameters such as the shape, thickness, period, and width of the metal nanoarray are determined. Its transmission spectrum produces a strong resonance peak at a certain wavelength.

[0022] Secondly, a multilayer structure (metal thin film layer 2-dielectric thin film layer 3-metal thin film layer 2) is grown on the glass substrate 1 by a material growth process, such as figure 2 (a) shown.

[0023] Then, through an etching process, a periodic metal nano-array 4 is prepared on the top metal thin film layer 2, as shown in the attached figure 2 (b) shown.

[0024] Finally, the biological samples to be tested with different refractive indices were placed on the surface of the nanostructure, as shown in the attached figure 2 As shown in (c)...

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Abstract

The invention provides a photon metasurface biosensor. A metal / dielectric / metal multilayer structure is grown on a glass substrate by a material growth process, wherein a metasurface is prepared on atop metal film layer by a dry or wet etching process; and at a particular wavelength, a very strong local surface plasmon resonance occurs between a metal nano-array and a dielectric layer. The transmittance at a center frequency of a transmission spectrum resonance peak is very sensitive to the change in a refractive index of a biological sample placed on a surface of the structure, so that biological samples having different refractive indexes can be detected by measuring a transmittance value at the center frequency of the transmission spectrum resonance peak. The photon metasurface biosensor provided by the invention has prominent advantages of small size, simple structure and easy realization, has a very broad application prospect in the field of biomedicine, and has important significance for development of biosensors.

Description

technical field [0001] The invention relates to a photon metasurface biosensor based on local surface plasmon resonance, which detects different biological samples by using the transmittance ratio at the peak of the transmittance spectrum. It can be applied in the field of disease diagnosis and treatment and biomedicine. Background technique [0002] With the rapid development of nano-manufacturing technology, the latest sensor technology can be used to analyze the bases of DNA, detect protein-protein interaction, surface membrane binding technology and antigen-antibody recognition, etc. Among them, the surface plasmon resonance (Surface Plasmon Resonance, SPR) sensor can detect the interaction between biological samples (such as antigens, DNA) and specific binding partners (such as antibodies, complementary DNA) immobilized on the structure. Mark measurements. Due to its label-free, minimal interference and real-time monitoring functions, nanoscale biological detection te...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/59
CPCG01N21/59G01N2021/5903
Inventor 郑光召曹暾钟明军
Owner DALIAN UNIV OF TECH
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