Tyroserleutide-chlorin e6 monoester and preparation method thereof
A technique of chlorin and leupepide, which is applied in the field of tyroserupin-chlorin e6 monoester, and can solve the problems of tumor growth inhibition, no reports on tyroserupin and chlorin, etc.
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[0024] Chlorin e6 (Chlorin e6, Ce6) is dissolved in ethanol under the condition of protective gas and dark, and it is A. After tyroserleutide was dissolved in glacial acetic acid, A was added, and the reaction was carried out under stirring at 36°C for 28 hours; wherein chlorin e6 (Chlorin e6, Ce6) and tyroserleutide were in equimolar amounts.
[0025] After centrifugation, the supernatant was dialyzed against deionized water and freeze-dried.
[0026] The dry matter is separated by silica gel column chromatography, and the eluent is a mixed solution of dichloromethane / methanol with a volume ratio of 3 / 7 to 7 / 3;
[0027] After dichloromethane / methanol is evaporated, dissolve with methanol or acetonitrile, refine and purify with reverse phase column chromatography, the eluent is methanol / water mixed solution or acetonitrile / water mixed solution; the filler used in the reversed phase column is C 18 ; The volume ratio of the methanol / water mixed solution or the acetonitrile / wate...
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