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Pharmaceutical composition with synergistic effect for treating pancreatic cancer

A technology for the treatment of drugs and pancreatic cancer, applied in the field of drugs to achieve the effects of low drug toxicity and improved sensitivity

Active Publication Date: 2018-10-26
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, adenosine and the combination of adenosine and other small molecular compounds for the preparation of pancreatic cancer therapeutic drugs have not been reported yet.

Method used

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  • Pharmaceutical composition with synergistic effect for treating pancreatic cancer
  • Pharmaceutical composition with synergistic effect for treating pancreatic cancer
  • Pharmaceutical composition with synergistic effect for treating pancreatic cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] 1. Experimental method

[0047] (1) Reagents

[0048] GSK690693 was purchased from selleck company.

[0049] Adenosine was purchased from Sigma-Aldrich Company and dissolved in a medium containing 10% fetal bovine serum. DMEM medium, RPMI-1640 medium, Opti-MEM medium, fetal bovine serum, propidium iodide, Lipofectamine TM RNAiMax transfection reagent was purchased from Thermo Fisher Scientific. DTT, bromophenol blue, crystal violet, protease inhibitor cocktail, aging-related β-gal staining kit, and paraformaldehyde were purchased from Sigma-Aldrich. RIPA lysate, PMSF, 30% acrylamide, 1M Tris solution (pH8.8 / pH6.6), ammonium persulfate, TEMED, and ROS detection kit were purchased from Shanghai Biyuntian Biotechnology Co., Ltd. ECL chromogenic solution was purchased from Beijing Kangwei Reagent Biotechnology Co., Ltd. PVDF membranes were purchased from Millipore Corporation. Biostep protein standard molecular weight was purchased from Shanghai Tianneng Technology C...

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Abstract

The invention relates to the technical field of drugs and particularly relates to a pharmaceutical composition with a synergistic effect for treating pancreatic cancer. The pharmaceutical compositioncontains adenosine and an Akt inhibitor. The pharmaceutical composition has the advantages that by utilizing a drug provided by the invention, apoptosis cascade signals in pancreatic cancer cells canbe activated, meanwhile, a mechanism that pancreatic cancer cells resist the killing of the drug through aging signals is weakened, so that the in-vivo multiplication of pancreatic cancer is inhibited; and by utilizing the Akt inhibitor, the sensitivity of pancreatic cancer to exogenous adenosine is improved, and meanwhile, relatively low drug toxicity is maintained, so that a new strategy is provided for the treatment of pancreatic cancer.

Description

technical field [0001] The invention relates to the technical field of drugs, in particular to a drug combination for treating pancreatic cancer with synergistic effect. Background technique [0002] Pancreatic cancer is a common and deadly malignant tumor worldwide. The median survival period of its patients is only 3-6 months, and the 5-year survival rate is less than 5%. Worldwide, pancreatic cancer kills more than 200,000 people each year. According to statistics in 2010, the number of deaths from pancreatic cancer in China was 57,735 that year, surpassing the number of deaths from pancreatic cancer in the United States in the same year. From a global perspective, although the incidence and mortality of pancreatic cancer in my country are relatively low, the ratio of the mortality rate to the prevalence of pancreatic cancer in my country has reached 0.89, which is significantly higher than that in North America, Australia and other high-incidence areas of pancreatic ca...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/7076A61K31/4545A61P35/00
CPCA61K31/4545A61K31/7076A61K45/06A61P35/00A61K2300/00
Inventor 杨冬琴章琦张文丽车智慧吴梦梦汤子慧
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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