Responding type gold nano-cluster particles for blood glucose regulation and preparation method of responding type gold nano-cluster particles

Abstract

The invention discloses responding type gold nano-cluster particles for blood glucose regulation and a preparation method of the responding type gold nano-cluster particles, and belongs to the field of biomedicine. The responding type gold nano-cluster particles comprise a carrier material, a glucose responding sensitive switch factor and pharmaceutical molecules. The preparation method comprisesfollowing steps: firstly, preparing BSA-coated gold nano-cluster particles BSA-GNCs to serve as the carrier material of the pharmaceutical molecules; removing amino on BSA molecules by glutaraldehyde,converting tail ends of the molecules into carboxyl by glycine, activating carboxyl, and grafting and modifying carboxyl with 4-aminophenylboronic acid to serve as the glucose responding sensitive switch factor; grafting the glucose responding sensitive switch factor with glycosylated insulin to obtain the responding type gold nano-cluster particles for blood glucose regulation. The gold nano-cluster particles can release insulin according to glucose concentration response; functions of responding to glucose concentration in real time, rapidly and intelligently transmitting and releasing insulin and regulating blood glucose of a human body are achieved.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a gold nano-cluster particle for responsive blood sugar regulation and a preparation method thereof. Background technique [0002] Diabetes is a group of major chronic metabolic diseases characterized by hyperglycemia. Relative or absolute insufficiency of insulin in the human body leads to hyperglycemia, which is the root cause of diabetes. Diabetes has become the third major factor endangering human health. According to statistics, there were 420 million diabetics in the world in 2016, and this number will increase to 629 million by 2045. [0003] Real-time monitoring of blood glucose concentration in the body and timely injection of insulin are the keys to effective control of diabetes. At present, the vast majority of diabetic patients are treated with insulin, that is, taking insulin by injection or orally to regulate blood sugar. The specific treatment method is to monitor the...

AI Technical Summary

Problems solved by technology

Long-term frequent subcutaneous insulin injections bring severe psychological pressure to patients and affect their quality of life

At the same time, if the injection dose cannot be accurately controlled, it is easy to cause hyperglycemia or hypoglycemia, which can induce serious complications, or the low blood glucose concentration in the patient's body will endanger life and health.

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