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Biflavonoid compound and application thereof

A technology of bisflavonoids and compounds, applied in the field of pharmacy, can solve the problem of enhancing the damage effect of carboplatin

Active Publication Date: 2018-09-28
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The results showed that C-3′-C-8″ biflavonoid compounds can significantly enhance the damage effect of carboplatin on cancer cells, while monoflavone (8) and other linking biflavonoid compounds (9-10) have no Synergistic sensitization (Table 2)

Method used

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  • Biflavonoid compound and application thereof
  • Biflavonoid compound and application thereof
  • Biflavonoid compound and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 The in vitro cell activity screening of the biflavones

[0022] 1.1 Test materials and instruments

[0023] 1.1.1 Test materials

[0024]A549 cells, HepG2 cells, Ovarian cells (BRCA gene deficient) Shanghai Cell Bank of Chinese Academy of Sciences; nude mice, Model Animal Center of Nanjing University; DMEM medium, Nanjing KGI Biotechnology Development Co., Ltd.; fetal bovine serum, ScienCell, USA; Anti (penicillin, streptomycin) Nanjing Kaiji Biotechnology Co., Ltd.; trypan blue, Canada BioBasic Co., Ltd.; thiazolyl tetrazolium (MTT), Nanjing Kaiji Biotechnology Development Co., Ltd.; Its structural analogs are isolated from Selaginella chinensis (S.Mollendorfii), and their structures are identified by NMR, MS and other spectral methods, with a purity of >95%.

[0025] 1.1.2 Test equipment:

[0026] Microplate reader, Tecan, Switzerland; Inverted fluorescence microscope, Nikon, Japan

[0027] 1.2 Test methods and results

[0028] 1.2.1 PARP-1 activity inh...

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Abstract

The invention discloses a biflavonoid compound and application thereof, belongs to the field of natural pharmaceutical chemistry and pharmacotherapy, and particularly relates to a C-3'-C-8''-type biflavonoid compound or pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the compound, medical application thereof, particularly application thereof as a chemotherapeuticplatinum medicine sensitizer, and a therapeutic effect on BRCA gene defect-type advanced ovarian cancer.

Description

technical field [0001] The present invention relates to a C-3'-C-8" type biflavonoid compound, its application in the treatment of liver cancer, lung cancer chemotherapeutic platinum drug sensitization, and its effect on BRCA gene deficient advanced ovarian cancer The therapeutic effect belongs to the technical field of pharmacy. Background technique [0002] Malignant tumors seriously endanger human life and health, and have become one of the main causes of death from diseases today. At present, the main treatment methods for malignant tumors include surgery, radiotherapy and chemotherapy. Chemotherapy is a better option for patients diagnosed with advanced tumors and those with metastases. Clinicians can optimize the maximum curative effect and minimum toxicity by adjusting the dosage of drugs, helping patients prolong survival time and improve the prognosis of life quality. However, the generation of drug resistance of tumor cells leads to a decline in the sensitivity ...

Claims

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Application Information

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IPC IPC(8): C07D311/30A61K31/352A61K33/24A61K31/555A61P35/00
CPCA61K31/352A61K31/555A61K33/24A61P35/00C07D311/30A61K2300/00
Inventor 汪豪胡晓龙熊非叶文才
Owner CHINA PHARM UNIV
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