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Composite disruptor composition as well as preparation and application thereof

A compound interferon and composition technology, applied in the field of compound interferon and its application, can solve the problems of interferon research lag and other problems, achieve the effect of avoiding gastric acid and liver metabolism, having no toxic side effects, and promoting disease prevention and treatment

Inactive Publication Date: 2018-09-28
THE INST OF BIOTECHNOLOGY OF THE CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, China has commercialized human genetically engineered interferon on the market, but the research on interferon for animals is relatively lagging behind. Although there have been many reports of successful cloning of interferon, only a few commercial products have been launched

Method used

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  • Composite disruptor composition as well as preparation and application thereof
  • Composite disruptor composition as well as preparation and application thereof
  • Composite disruptor composition as well as preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The effect of the composite interferon composition of embodiment 1 different addition ratios on broiler growth body weight

[0044] 1. Experimental method

[0045] 1.1 Grouping and handling of experimental animals

[0046] The chicken α and γ interferon of the corresponding antiviral activity unit (IU) were mixed in different ratios (1:0; 1:1; 1:2; 1:4; 1:8; 8:1; 4:1; 2:1; 0:1), for the accuracy of the experiment, the compound interferon composition was fed by gavage. The experiment adopted a single-factor completely randomized grouping design. 360 healthy 20-day-old broilers (7-day-old routine immunization) were selected and randomly divided into 9 groups, with 5 repetitions in each group and 8 chickens in each repetition. Drinking water and feed in the early and late stages were all purchased from Beijing Zhengda Feed Company. The test groups were fed with different proportions of compound interferon compositions for 5 consecutive days. The control group was fed wit...

Embodiment 2

[0061] The influence of embodiment 2 different doses of composite interferon composition on broiler growth body weight

[0062] 1. Experimental method

[0063] 1.1 Grouping and handling of experimental animals

[0064] According to the measurement result of compound expression interferon, the chicken alpha and gamma interferon of corresponding antiviral activity unit (IU) are mixed (1:2) by the preferred ratio of existing experiment (embodiment 1), for the accuracy of experiment , feeding and drinking the compound interferon composition by gavage. The experiment adopts a single-factor complete random grouping design, selects 240 healthy 20-day-old broiler chickens (refer to relevant literature results) (1-day-old routine immunization), and randomly divides them into 6 groups, with 5 repetitions in each group and 8 chickens in each repetition. There was no significant difference in body weight, free drinking water, and the pre- and post-feeds were purchased from Beijing Zheng...

Embodiment 3

[0074] Example 3 The Effect of Feeding and Drinking Different Doses of Composite Interferon Compositions on Broiler Feed-to-weight Ratio

[0075] 1. Experimental method

[0076] 1.1 Feeding and grouping of animals

[0077] Select 100 1-day-old healthy AA broilers. Under the test conditions, they were fed with complete feed for 2 weeks, and entered the test stage at the age of 20 days. The specific implementation is carried out according to the "Modern Broiler Production Manual". The formula refers to the NRC (1994) poultry nutrition standard and the dietary composition and nutritional components recommended by the "AA Broiler Breeding Manual".

[0078] At the age of 20 days (about 1000g in body weight), after eliminating smaller and larger individuals, select 120 chicks with basically the same body weight (P>0.1), and divide them into 3 treatment groups with 5 repetitions in each group. Repeat for 8 chickens. Weighed on an empty stomach before the experiment. In the test...

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Abstract

The invention discloses a composite disruptor composition as well as a preparation and application thereof. The composite disruptor composition disclosed by the invention comprises a chicken-alpha-disruptor and a chicken-gamma-disruptor. The composite disruptor composition is compounded from the chicken-alpha-disruptor and the chicken-gamma-disruptor, and can be made into various appropriate oralpreparations according to a conventional preparation method. The invention further discloses the application of the composite disruptor composition to promote growth of broilers or restrain poultry viruses, the application comprises: adding the composite disruptor composition to a feed or drinking water, and enabling the broilers to eat or drink. The composite disruptor composition has obvious effects of promoting weight increment, and reducing the feed-gain ratio for the broilers, and has precise restraining effect on various poultry viruses of Marek's disease viruses, newcastle disease viruses and the like, can reduce the attack rate of the broilers in the growth process, and is free from toxic and side effects and simple in using method.

Description

technical field [0001] The present invention relates to a compound interferon composition, in particular to a compound interferon composition comprising chicken α-interferon and chicken γ-interferon. The application in viruses belongs to the field of compound interferon and its application. Background technique [0002] China is a big poultry breeding country and a big consumer of poultry products. The rise and fall of the poultry farming industry directly affects China's national economy. At present, high-density intensive large-scale caged broiler or laying hens are the main mode of raising chickens. Due to the excessive density, the quality of the breeding environment has declined, which has created opportunities for the invasion of various pathogens, especially viruses. After the virus opened the defense door of the chicken body, various secondary bacterial diseases appeared, resulting in large-scale weight loss or death of the chicken flock. In order to improve the su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K20/147A23K50/75A61K38/21A61P31/22A61P31/14
CPCA61K38/212A61K38/217A23K20/147A23K50/75A61P31/14A61P31/22A61K2300/00
Inventor 张志芳姚斌胡小元李轶女杨鑫刘兴健马建爽王先翔宋浩志阿斯兰·梅赫布
Owner THE INST OF BIOTECHNOLOGY OF THE CHINESE ACAD OF AGRI SCI
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