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Granules for improving dyslipidemia and application thereof

A technology of dyslipidemia and granules, which is applied in the field of granules for improving dyslipidemia, can solve the problem that the research on hypolipidemic activity has not been reported, and can improve the changes of adipose tissue and cell morphology, and improve the level of high-density lipoprotein cholesterol. Effect

Inactive Publication Date: 2018-08-28
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the research on the hypolipidemic effect of Nitraria seeds is only limited to the hypolipidemic effect of Nitraria seed oil, and the research on the hypolipidemic activity of other parts of Nitraria seeds has not been reported.

Method used

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  • Granules for improving dyslipidemia and application thereof
  • Granules for improving dyslipidemia and application thereof
  • Granules for improving dyslipidemia and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The preparation of embodiment 1 Nitraria japonica seed extract granule:

[0037] This granule is made up of the weight percentage of following raw material:

[0038] Nitraria seed extract 55g, citric acid 3g, starch 15g, dextrin 15g.

[0039] The specific method is:

[0040] Weigh the raw materials according to the proportioning ratio, and prepare an aqueous citric acid solution with a mass concentration of 6-12%; mix the Nitraria seed extract, starch, and dextrin, pass through a 40-60 mesh sieve, and homogenize for 10-15 minutes; Add the good mixture into citric acid aqueous solution, stir and sieve to obtain coarse grains; pass the coarse grains through a 10-20 mesh sieve, dry, and granulate to obtain the required granules.

[0041] The preparation of Nitraria seed extract: after getting 5kg Nitraria seeds to pulverize through a high-speed universal pulverizer, extract with a solid-liquid ratio of 1:10kg / L in a Chinese medicine decocting machine, extraction time 2h,...

Embodiment 2

[0042] The preparation of embodiment 2 Nitraria japonica seed extract granules:

[0043] This granule is made up of the weight percentage of following raw material:

[0044] Nitraria seed extract 5g, citric acid 1g, starch 25g, dextrin 30g.

[0045] The specific method is:

[0046] Weigh the raw materials according to the proportioning ratio, and prepare an aqueous citric acid solution with a mass concentration of 6-12%; mix the Nitraria seed extract, starch, and dextrin, pass through a 40-60 mesh sieve, and homogenize for 10-15 minutes; Add the good mixture into citric acid aqueous solution, stir and sieve to obtain coarse grains; pass the coarse grains through a 10-20 mesh sieve, dry, and granulate to obtain the required granules.

[0047] The preparation of Nitraria seed extract: after getting 5kg Nitraria seeds to pulverize through a high-speed universal pulverizer, extract with a solid-liquid ratio of 1:14kg / L in a Chinese medicine decocting machine, extraction time 2h,...

Embodiment 3

[0048] The preparation of embodiment 3 Nitraria japonica seed extract granules:

[0049] This granule is made up of the weight percentage of following raw material:

[0050] Nitraria seed extract 30g, citric acid 2g, starch 20g, dextrin 25g.

[0051] The specific method is:

[0052] Weigh the raw materials according to the proportioning ratio, and prepare an aqueous citric acid solution with a mass concentration of 6-12%; mix the Nitraria seed extract, starch, and dextrin, pass through a 40-60 mesh sieve, and homogenize for 10-15 minutes; Add the good mixture into citric acid aqueous solution, stir and sieve to obtain coarse grains; pass the coarse grains through a 10-20 mesh sieve, dry, and granulate to obtain the required granules.

[0053] The preparation of Nitraria seed extract: after getting 5kg Nitraria seeds to pulverize through a high-speed universal pulverizer, extract with a solid-liquid ratio of 1:8kg / L in a Chinese medicine decocting machine, extraction time 2h, e...

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Abstract

The invention provides granules for improving dyslipidemia. The granules are prepared from the following raw and auxiliary materials in parts by weight: 5 to 55 parts of nitraria sibirica pall seed extract, 10 to 25 parts of starch, 5 to 30 parts of dextrin and 1 to 6 parts of flavoring agent, wherein the nitraria sibirica pall seed extract is prepared from the following method: taking nitraria sibirica pall seeds; taking an ethanol water solution as a solvent and extracting; after concentrating an extracting solution until the solution has no alcohol taste, extracting by utilizing a petroleumether-water system; taking a water layer and removing the solvent to obtain the nitraria sibirica pall seed extract. The invention further provides a preparation method and application of the granules. A research shows that the nitraria sibirica pall seed extract provided by the invention can be used for reducing total cholesterol, total triglyceride and low-density lipoprotein cholesterol in blood serum of hyperlipemia rats; meanwhile, pathological section observation on liver tissues of each group of the rats also finds out that the extract can be used for improving the changes of fat tissues and cell morphology of fatty livers in different degrees, and a new option is provided for clinical prevention or treatment of hyperlipidemia or the fatty livers.

Description

technical field [0001] The invention specifically relates to a granule for improving dyslipidemia, which uses the extract of the water part of Nitraria thorn seed as a raw material, and its application. technical background [0002] Hyperlipidemia is the main cause of atherosclerosis and related diseases such as coronary heart disease, ischemic brain disease and peripheral vascular disease. Although the incidence of diseases related to atherosclerosis has been improved due to drug treatment and prevention, the above conditions still account for a large proportion of morbidity and mortality in middle-aged and elderly people. Due to the increasing prevalence of obesity and the aging of the world population, the annual incidence and number will increase substantially in the next decade. Dyslipidemia is caused by abnormal blood lipid metabolism, such as the increase of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-C) and the decrease of high-density li...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/16A61K47/36A61P3/06A61P1/16A61K131/00
CPCA61K9/1652A61K36/185A61K2236/39A61K2236/35A61K2236/333
Inventor 胡娜索有瑞王洪伦
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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