Pharmaceutical composition for treating diabetes mellitus and complications thereof as well as preparation method and application of pharmaceutical composition

A technology of composition and complication, applied in the field of medicine, can solve problems such as limiting clinical application, and achieve the effects of improving sensitivity, improving symptoms, and improving antioxidant capacity

Inactive Publication Date: 2018-08-24
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, metformin, sulfonylureas, α-glucoside inhibitor oral hypoglycemic agents and insulin injections are clinically commonly used drugs for the treatment of diabetes and require long-term use, but these drugs are often accompanied by various side effects, which limit their clinical application

Method used

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  • Pharmaceutical composition for treating diabetes mellitus and complications thereof as well as preparation method and application of pharmaceutical composition
  • Pharmaceutical composition for treating diabetes mellitus and complications thereof as well as preparation method and application of pharmaceutical composition
  • Pharmaceutical composition for treating diabetes mellitus and complications thereof as well as preparation method and application of pharmaceutical composition

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Experimental program
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Effect test

preparation example Construction

[0035] The preparation method of this pharmaceutical composition (the first composition) comprises:

[0036] (1) Pulverize Coptis Rhizoma, Radix Astragali, Radix Scutellariae and Radix Glycyrrhiza in parts by weight to obtain a mixed medicinal powder, and then squeeze fresh rehmannia root and Trichosanthes root to obtain medicinal juice;

[0037] Preferably, fresh Trichosanthes root is used, and the medicinal juice is obtained by pressing fresh Rehmannia glutinosa and fresh Trichosanthes root.

[0038] (2) Mix the mixed medicine powder with the medicine juice, and after the medicine juice is basically absorbed, it is mixed with pharmaceutically acceptable excipients to make pills or other dosage forms.

[0039] The pharmaceutical composition (second composition) also includes: 2-6 parts of angelica, 2-5 parts of schisandra, 1-4 parts of peach gum polysaccharide, and 2-5 parts of raw Ophiopogon japonicus.

[0040] Further, in terms of parts by weight, 3-5 parts of angelica, 3-...

Embodiment 1

[0073] The present embodiment provides a kind of pharmaceutical composition, it comprises:

[0074] Coptis 5kg, fresh rehmannia 9kg, astragalus 2kg, scutellaria baicalensis 7kg, Trichosanthes root 3kg, licorice 5kg.

[0075] The preparation method of this pharmaceutical composition comprises:

[0076] a. According to the formula quantity, grind Coptis chinensis, Astragalus membranaceus, Scutellaria baicalensis and peach gum polysaccharide into coarse powder to obtain mixed medicinal powder, then squeeze fresh rehmannia glutinosa and Trichosanthes root to obtain medicinal juice;

[0077] b. Mix and soak the mixed medicinal powder and medicinal juice, and after the mixed medicinal powder absorbs the medicinal juice, it is mixed with pharmaceutically acceptable auxiliary materials to make a pill.

Embodiment 2

[0079] The present embodiment provides a kind of pharmaceutical composition, it comprises:

[0080] Coptis 9kg, fresh rehmannia 5kg, astragalus 7kg, scutellaria baicalensis 2kg, Trichosanthes root 8kg, licorice 2kg.

[0081] Its preparation method is consistent with embodiment 1.

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Abstract

The invention provides a pharmaceutical composition for treating diabetes mellitus and complications thereof as well as a preparation method and application of the pharmaceutical composition and belongs to the field of medicines. The pharmaceutical composition is prepared from rhizoma coptidis, radix rehmanniae, radix astragali seu hedysari, radix scutellariae, radix trichosanthes and liquorice root. The preparation method of the pharmaceutical composition comprises the following steps: crushing the rhizoma coptidis, the radix astragali seu hedysari, the radix scutellariae and the liquorice root in parts by weight to obtain mixed medicine powder; then squeezing the radix rehmanniae and the radix trichosanthes to obtain medicine juice; mixing the mixed medicine powder with the medicine juice; after the medicine juice is completely absorbed by the mixed medicine powder, mixing with pharmaceutically acceptable auxiliary materials to prepare a preparation. According to the pharmaceutical composition provided by the invention, the sensitivity of tissues on insulin can be improved through improving insulin resistance, and the anti-oxidization capability of organisms is improved; the blood glucose is remarkably reduced and symptoms of polydipsia, polyuria, polyphagia and weight loss are improved; meanwhile, the pharmaceutical composition has certain adjustment on glycolipid metabolismand can be used for preventing the complications from occurring; the effect of the pharmaceutical composition is better than that of dimethyldiguanide.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a pharmaceutical composition for treating diabetes and its complications, a preparation method and application thereof. Background technique [0002] Diabetes is a metabolic disorder, characterized by hyperglycemia and various complications based on the disorder of glucose metabolism. "symptom. Among them, type 2 diabetes accounts for the vast majority, mainly manifested in varying degrees of relative insulin deficiency or insulin resistance. [0003] At present, metformin, sulfonylureas, α-glucoside inhibitor oral hypoglycemic agents and insulin injections are clinically commonly used drugs for the treatment of diabetes and require long-term use, but these drugs are often accompanied by various side effects, which limit their clinical application. [0004] In view of this, propose this patent. Contents of the invention [0005] The object of the present invention is to provide a p...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61K36/9068A61K36/8968A61P3/10A61K31/715
CPCA61K31/715A61K36/076A61K36/232A61K36/258A61K36/284A61K36/428A61K36/481A61K36/484A61K36/488A61K36/539A61K36/57A61K36/718A61K36/734A61K36/736A61K36/79A61K36/804A61K36/8968A61K36/8994A61K36/9068A61P3/10A61K2300/00
Inventor 任永申梅之南杜冬云雷蕾王丽君李燕
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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