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Hypotensive extract

A technology of extract and solution, which is applied in the field of biological blood pressure reduction, can solve the problems of high price and life-long consumption, and achieve the effect of improving purity, lowering blood pressure, and improving blood pressure lowering effect

Inactive Publication Date: 2018-08-10
磐安县派普特生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But these drugs are expensive and take for life

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] An extract for reducing blood pressure, which is rich in gamma-aminobutyric acid; the preparation method of the extract for reducing blood pressure comprises the following steps:

[0015] 1) Freezing and thawing to break the wall: add 2.5-5% sulfosalicylic acid solution in the laver mud, and the mass volume ratio of laver mud and sulfosalicylic acid solution is 1g: 0.6-2.0ml. The sulfosalicylic acid solution contains 0.002~0.004% alloisoleucine and 0.0001~0.0003% N,N-di-n-propyl-m-toluidine; the composition of the alloisoleucine is 80~ 85% D-alloisoleucine and 15~20% L-alloisoleucine. Freeze at -35~-25°C, thaw at 10~20°C, repeat freeze-thaw times 1~3 times, extract by ultrasonic for 30~50min after freeze-thaw, and then 8000~12000r at 2~6°C Centrifuge for 6~15min at 1 / min, save the supernatant;

[0016] 2) Salt-out: Add ammonium sulfate and PEG4000 to the supernatant, so that the concentration of ammonium sulfate in the solution reaches 20-35%, and the concentration of...

Embodiment 2

[0020] An extract for reducing blood pressure, which is rich in gamma-aminobutyric acid; the preparation method of the extract for reducing blood pressure comprises the following steps:

[0021] 1) Freezing and thawing to break the wall: add 2.5-5% sulfosalicylic acid solution in the laver mud, and the mass volume ratio of laver mud and sulfosalicylic acid solution is 1g: 0.6-2.0ml. The sulfosalicylic acid solution contains 0.002~0.004% alloisoleucine and 0.0001~0.0003% N,N-di-n-propyl-m-toluidine; the composition of the alloisoleucine is 80~ 85% D-alloisoleucine and 15~20% L-alloisoleucine. Freeze at -35~-25°C, thaw at 10~20°C, repeat freeze-thaw times 1~3 times, extract by ultrasonic for 30~50min after freeze-thaw, and then 8000~12000r at 2~6°C Centrifuge for 6~15min at 1 / min, save the supernatant;

[0022] 2) Salt-out: Add ammonium sulfate and PEG4000 to the supernatant, so that the concentration of ammonium sulfate in the solution reaches 20-35%, and the concentration of...

Embodiment 3

[0026] An extract for reducing blood pressure, which is rich in gamma-aminobutyric acid; the preparation method of the extract for reducing blood pressure comprises the following steps:

[0027]1) Freezing and thawing to break the wall: add 2.5-5% sulfosalicylic acid solution in the laver mud, and the mass volume ratio of laver mud and sulfosalicylic acid solution is 1g: 0.6-2.0ml. The sulfosalicylic acid solution contains 0.002~0.004% alloisoleucine and 0.0001~0.0003% N,N-di-n-propyl-m-toluidine; the composition of the alloisoleucine is 80~ 85% D-alloisoleucine and 15~20% L-alloisoleucine. Freeze at -35~-25°C, thaw at 10~20°C, repeat freeze-thaw times 1~3 times, extract by ultrasonic for 30~50min after freeze-thaw, and then 8000~12000r at 2~6°C Centrifuge for 6~15min at 1 / min, save the supernatant;

[0028] 2) Salt-out: Add ammonium sulfate and PEG4000 to the supernatant, so that the concentration of ammonium sulfate in the solution reaches 20-35%, and the concentration of ...

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Abstract

The invention discloses a hypotensive extract, which contains rich gamma-aminobutyric acid. Seaweed is used as raw materials to obtain the hypotensive extract through freezing and thawing wall-breaking, salt precipitation and ultrafiltration purification. The hypotensive extract has the beneficial effects that ammonium sulfate and PEG4000 are added into supernate; the purity of the hypotensive extract is improved. The hypotensive extract obtained through extraction contains rich gamma-aminobutyric (GABA); after the eating, the activity of angiotensin I transferase (ACE) can be effectively inhibited; the content of angiotensin II in blood serum is reduced through lowering the conversion rate of the decapeptide angiotensin I, so that the blood pressure is reduced. The hypotensive extract provided by the invention lowers the blood pressure by regulating an RAS (Renin-angiotensin system); after the long-time eating, the content of the angiotensin II (ANG-II) in the human body blood serum is reduced; the NO content is increased.

Description

technical field [0001] The invention relates to the field of biological blood pressure reduction, in particular to an extract for blood pressure reduction. Background technique [0002] Hypertension is an abnormal condition in which arterial blood pressure exceeds normal values. Some people's blood cannot pass through the whole body smoothly due to various reasons, such as blood vessel narrowing caused by some reason. At this time, the pressure of blood vessels increases, which can also cause high blood pressure. Hypertension is defined as systolic blood pressure ≥ 140mmHg and diastolic blood pressure ≥ 90mmHg. High blood pressure can easily lead to stroke, myocardial infarction, coronary heart disease, chronic renal failure and other complications, which seriously endanger human health. Western medicine believes that sympathetic hyperactivity is the main cause of high blood pressure; then there are ACE inhibitors and other drugs for the treatment of high blood pressure. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/04A61K31/197A61P9/12
CPCA61K36/04A61K31/197A61K2236/333A61K2236/53A61P9/12
Inventor 陈雨诗
Owner 磐安县派普特生物科技有限公司
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