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Preparation method of turmeric extract

A technology of turmeric extract and weight, applied in the field of preparation of turmeric extract, can solve problems such as anti-cancer, which is not paid attention to, achieve the effects of facilitating the operation of workshop workers, solving difficult drying and low equipment requirements

Inactive Publication Date: 2018-07-31
SHINEWAY PHARMA GRP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, all patents only emphasize the extraction and purification of curcumin, and do not pay attention to demethoxycurcumin and bisdemethoxycurcumin, which have more significant anti-cancer and anti-oxidation effects. The turmeric extract prepared by this patent contains turmeric Curcumin, demethoxycurcumin and bisdemethoxycurcumin, and the ratio between the three fully meets the requirements of Jiangzhitongluo Soft Capsules for turmeric extract, and the turmeric extract in Jiangzhitongluo Soft Capsules The ratio of ingredients has been experimentally verified to be the best ratio

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Weigh 1 kg of turmeric medicinal powder, put it into an extraction bottle, add 5 times the amount of 50% ethanol, and extract twice at 55°C for 2 hours and 1.5 hours respectively. After the extraction is completed, extract the upper layer of the extract, combine the extracts, filter to obtain the filtrate, and concentrate it in a vacuum to 0.1 times the weight of the medicinal material. Add ethanol in the amount of about 0.25 times the weight of the paste to the paste, stir well until it dissolves, and let it stand in the refrigerator for 24 hours to remove the insoluble matter at the bottom of the bucket and weigh it. Add petroleum ether (60-90°C) with the same volume (g / ml) of the paste weight, stir evenly, stir for 30 minutes at a time, and let stand for 24 hours. Extract the upper petroleum ether layer and discard it. Concentrate the lower extract in vacuum to 0.05 times the weight of the medicinal material to produce an ointment. Add 0.4 times the amount (g / g) of ...

Embodiment 2

[0033] Weigh 1 kg of turmeric medicinal powder, put it into an extraction bottle, add 8 times the amount of 70% ethanol, and extract twice at 60°C for 3 hours and 2 hours respectively. After the extraction is completed, the upper extract is extracted, and the extracts are combined, filtered to obtain the filtrate, and concentrated in vacuo to 0.14 times the weight of the medicinal material. Add ethanol in the amount of about 0.25 times the weight of the paste to the paste, stir well until it dissolves, and let it stand in the refrigerator for 18 hours to remove the insoluble matter at the bottom of the bucket and weigh. Add 1.5 times the volume (g / ml) of the petroleum ether (60-90°C) of the paste weight, stir evenly, stir for 10 minutes at a timing, and let stand for 24 hours. Extract the upper petroleum ether layer and discard it. The lower extract is vacuum concentrated to 0.1 times the weight of the medicinal material to make a paste. Add 0.4 times the amount (g / g) of 90% ...

Embodiment 3

[0035] Weigh 1 kg of turmeric medicinal powder, put it into an extraction bottle, add 6 times the amount of 95% ethanol, and extract three times at 50°C for 3 hours, 2 hours and 1.5 hours respectively. After the extraction is completed, the upper layer of the extract is extracted, and the extract is combined, filtered to obtain the filtrate, and concentrated in vacuo to 0.2 times the weight of the medicinal material. Add ethanol in the amount of about 0.25 times the weight of the paste to the paste, stir well until it dissolves, and let it stand in the refrigerator for 12 hours to remove the insoluble matter at the bottom of the bucket and weigh it. Add petroleum ether (60-90°C) twice the volume (g / ml) of the paste weight, stir evenly, stir for 20 minutes at a timing, and let stand for 24 hours. Extract the upper petroleum ether layer and discard it. The lower extract is concentrated in a vacuum to 0.1 times the weight of the medicinal material. Add 0.4 times the amount (g / g)...

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PUM

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Abstract

The invention provides a preparation method of turmeric extract. The turmeric extract is prepared from radix curcuma through crushing, alcohol extraction, concentration, extraction, crystallization, washing and drying. The product has a gorgeous color. The turmeric extract contains 45.0%-70.0% of curcumin (C21H20O6), demethoxycurcumin (C20H18O5) and bisdemethoxycurcumin (C19H16O4), the total ratioof the curcumin (C21H20O6), demethoxycurcumin (C20H18O5) and bisdemethoxycurcumin (C19H16O4) is greater than the curcumin compound content of 93.0% and the content of compound (C21H20O6) is 40.0%-60.0%. The product fully satisfies the requirements on use of soft capsules with effects of reducing blood fat and dredging collaterals. The method utilizes a one-step extraction method and a two-step alcohol precipitation method, ensures the quality of the turmeric extract, has simple processes, realizes obvious oil removal effects, is conducive to product drying, has stable processes and is suitable for industrial production.

Description

Technical field [0001] The invention relates to a preparation method of a turmeric extract, belonging to the technical field of extraction and separation of natural plant active ingredients. Background technique [0002] Turmeric is the dried rhizome of Curcuma longa L., a plant belonging to the ginger family, Curcuma longa L., a perennial herb, and a commonly used traditional Chinese medicine in the "Chinese Pharmacopoeia"; it has a bitter taste and is warm in the spleen and liver channels. The effect of. The main active ingredient is curcumin compounds, including three active ingredients, namely curcumin, demethoxycurcumin, and bisdemethoxycurcumin. [0003] Modern medical research shows that curcumin has the effects of antioxidant, anti-inflammatory, lipid-lowering, liver protection, anti-tumor, anti-fertility, anti-depression, and prevention of Alzheimer's disease. Curcumin is also a widely used food additive at home and abroad, so curcumin is one of It is a kind of natural, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K31/12A61P3/06
CPCA61K36/9066A61K31/12A61K2236/333A61K2236/35A61K2236/51A61K2236/53A61K2236/55
Inventor 冯玉康郝鹏彬李菲杨琴丁艳谱王文鹏孙胜斌姜国志陈钟李振江
Owner SHINEWAY PHARMA GRP LTD
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