Method for preparing Crisaborole soluble film preparations and application thereof

A cleaborol, soluble technology, applied in the field of sustained release of new drugs, can solve the problems of greasy feeling, loss of active ingredients, and low drug penetration, and achieve the effect of highlighting substantive characteristics and improving stability

Inactive Publication Date: 2018-07-27
SUZHOU ZHIYU BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional ointment contains a large amount of Vaseline, which has a strong greasy feeling during use, easily stains clothes, and loses a considerable part of the active ingredients.

Method used

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  • Method for preparing Crisaborole soluble film preparations and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1---select the fatty acid salt of chain length 9 in above-mentioned step S1 as dispersant raw material, and the ultrasonic intensity of gas dispersion in step S2 is 65W / m 2 . In this example, step S3 is used as the end point of the treatment of criborol, and the mono-distributed cribronol soluble film preparation obtained in step S3 is used to infiltrate or coat the gauze, and combine with the adhesive tape to form a mono-distributed creborol-containing film preparation. of adhesive strips. In this way, the user can directly attach an adhesive strip on the surface of the affected area like a Band-Aid, so that the criborole can be gradually released from the gauze and penetrate into the affected area, gradually realizing the curative effect of the criborole drug.

Embodiment 2

[0017] Embodiment 2---select the hydroxyalkyl sulfonate of chain length 5 in above-mentioned step S1 as dispersant raw material, and the ultrasonic intensity of gas dispersion in step S2 is 78W / m 2 . In this example, step S3 is used as the end point of the treatment of criborol, and the mono-distributed cribronol soluble film preparation obtained in step S3 is used to infiltrate or coat the gauze, and combine with the adhesive tape to form a mono-distributed creborol-containing film preparation. of adhesive strips. In this way, the user can directly attach an adhesive strip on the surface of the affected area like a Band-Aid, so that the criborole can be gradually released from the gauze and penetrate into the affected area, gradually realizing the curative effect of the criborole drug.

[0018] The preparation and treatment method and multi-application mode of creborone of the present invention have outstanding substantive characteristics and remarkable progress: such as fi...

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Abstract

The invention discloses a method for locally releasing Crisaborole in a sustained manner. The method includes a method for preparing Crisaborole soluble film preparations. The method for preparing theCrisaborole soluble film preparations is characterized by comprising steps of S1, selecting ionic active agents with (-CH2-) and the chain lengths of 3-15 to be used as raw materials for dispersing agents, and selecting alcohol substances to be used as stabilizers for the corresponding dispersing agents; S2, carrying out gas dispersion on Crisaborole original medicines in the ultrasonic intensityranges of 60-80 W / m<2>, then adding the raw materials for the dispersing agents, carrying out treatment in room-temperature keeping environments for 20-40 minutes, adding the stabilizers, and carrying out ultrasonic treatment under identical intensity conditions for 20-30 minutes to form wide distribution stock solution; S3, continuously filtering the stock solution by the aid of filter paper with the filter hole specifications of 0.22 micrometer by 2-3 times and collecting filter liquor to obtain the single-distribution Crisaborole soluble film preparations with the sizes of 0.10-0.15 micrometer. According to the technical scheme, the method has the advantages that the ionic active agents with the appropriate lengths are selected, the ultrasonic intensity is controlled, accordingly, finished medicine products with uniformly dispersed particle sizes and stable and controllable release curves can be obtained, and the practicality can be improved.

Description

technical field [0001] The invention relates to a slow-release method of a novel drug, in particular to a drug slow-release method for ulcerative skin diseases and psoriasis and its application. Background technique [0002] Among many diseases, skin diseases such as psoriasis, local ulcers and other minor symptoms often do not attract extensive attention, so in most cases, they will develop to the point where they are unmanageable. The reason is that it is not easy to find in the early stage of the disease, and there is a lack of targeted treatment methods. Patients often fear the trouble of seeking medical care. [0003] Usually, sprains and bumps can be treated by wiping or spraying Yunnan Baiyao, and small incisions can be treated by attaching a Band-Aid. For this reason, it is particularly important to seek a simple, targeted and rapid treatment method for the above-mentioned hidden dermatological diseases. [0004] In recent years, a new drug called Crisaborole (Eng...

Claims

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Application Information

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IPC IPC(8): A61K31/69A61P17/02A61P17/06A61K9/70
Inventor 付任重李建民陈航平肖海英马义成杨博
Owner SUZHOU ZHIYU BIOTECH CO LTD
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