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Lysozyme-modified medical gauze

A technology of lysozyme and gauze, applied in the fields of medical science, coating, absorbent pad, etc., can solve the problems of complex preparation process, poor permeability, unfavorable human health of nano-silver, etc., and achieves simple and mild preparation process, low cost, The effect of speeding up wound healing

Pending Publication Date: 2018-07-24
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problems that the existing non-stick gauze has poor water absorption and water vapor permeability, complex preparation process and nano silver is not conducive to human health, the present invention combines lysozyme under the action of tris(2-carboxyethyl) phosphate hydrochloride to easily The amyloid-like transformation occurs, the assembly adhesion on the solid surface and the lysozyme coating have the characteristics of efficient contact sterilization, providing a lysozyme-modified medical gauze

Method used

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  • Lysozyme-modified medical gauze
  • Lysozyme-modified medical gauze
  • Lysozyme-modified medical gauze

Examples

Experimental program
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Effect test

Embodiment 1

[0024] 50mmol / L tris(2-carboxyethyl)phosphine hydrochloride aqueous solution was adjusted to pH 6.2 with 5mol / L sodium hydroxide aqueous solution. Take 10mL of 2mg / mL lysozyme aqueous solution (prepared by adding 20mg of lysozyme to 10mL of deionized water) and 10mL of 50mmol / L tris(2-carboxyethyl)phosphine hydrochloride aqueous solution with pH=6.2 and mix them, then soak the absorbent cotton gauze into the mixed solution, soak at room temperature for 60 minutes, take out the gauze, soak and wash it with deionized water three times, and dry at 60°C to obtain lysozyme-modified medical gauze.

[0025] Scanning electron microscopy was used to characterize the absorbent cotton gauze before modification and the lysozyme modified medical gauze, the results are shown in figure 1 with 2 . It can be seen from the figure that the surface of the modified gauze is covered with a layer of lysozyme nanofilm.

[0026] According to the method described in national standard YY / T 0471.1-200...

Embodiment 2

[0030] A 50 mmol / L tris(2-carboxyethyl)phosphine hydrochloride aqueous solution was adjusted to pH 5 with a 5 mol / L sodium hydroxide aqueous solution. Take 10mL of 2mg / mL lysozyme aqueous solution (prepared by adding 20mg of lysozyme to 10mL of deionized water) and 10mL of 50mmol / L tris(2-carboxyethyl)phosphine hydrochloride aqueous solution with pH=5, mix them, and then soak the absorbent cotton gauze into the mixed solution, soaked at room temperature for 60 minutes, took out the gauze, soaked it in deionized water, washed it three times, and dried it at 60°C to obtain the lysozyme-modified medical gauze.

Embodiment 3

[0032] A 10 mmol / L tris(2-carboxyethyl)phosphine hydrochloride aqueous solution was adjusted to pH 8 with a 5 mol / L sodium hydroxide aqueous solution. Take 10mL 0.5mg / mL lysozyme aqueous solution (prepared by adding 5mg lysozyme to 10mL deionized water) and 10mL pH=8 10mmol / L tris(2-carboxyethyl)phosphine hydrochloride aqueous solution, mix them, and then put the absorbent cotton gauze Soak in the mixed solution, soak at room temperature for 60 minutes, take out the gauze, soak and wash it with deionized water three times, and dry at 60°C to obtain lysozyme-modified medical gauze.

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Abstract

The invention discloses lysozyme-modified medical gauze. A preparation method of the lysozyme-modified medical gauze comprises soaking absorbent cotton gauze in a mixed solution of a lysozyme aqueoussolution and tris(2-carboxyethyl)phosphine hydrochloride aqueous solution in a volume ratio of 1: 1 at the room temperature, then taking out the gauze, immersing and cleaning the gauze through deionized water and drying the gauze to obtain the lysozyme-modified medical gauze. The lysozyme-modified medical gauze has the characteristics that (1) there is no difference in water absorption and water vapor transmission performance of the gauze before and after modification, (2) compared with the unmodified gauze, the lysozyme-modified medical gauze treated by a vitamin C aqueous solution before replacement is easy to take off from the wound so that the secondary damage to the wound during the replacement process is avoided and the pain of the patient is reduced, (3) compared with the unmodifiedgauze, the lysozyme-modified medical gauze has bactericidal and anti-infection effects and can accelerate wound healing, and (4) the preparation method is simple and gentle, realizes a low cost and is suitable for large-scale production.

Description

technical field [0001] The invention belongs to the technical field of surface modification of wound dressings, and specifically relates to a lysozyme-modified medical gauze. Background technique [0002] The skin is the largest organ of the human body and a natural barrier to protect the body. For patients with severe skin defects, a large amount of body fluid loss and wound infection are the main factors that threaten the life of the patient. As a temporary cover for the wound, the wound dressing can provide a relatively stable healing environment for the wound surface and play an important role in the process of wound healing. important role. Traditional absorbent cotton gauze has significant advantages such as wide sources of raw materials, simple preparation, and low cost, and is widely used in the clinical treatment of various wounds. However, the following disadvantages of traditional gauze limit its application in complex wounds, especially chronic wounds: first, i...

Claims

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Application Information

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IPC IPC(8): A61L15/38A61L15/46A61L15/44
CPCA61L15/38A61L15/44A61L15/46A61L2300/254A61L2300/404A61L2300/412A61L2420/02
Inventor 杨鹏赵健
Owner SHAANXI NORMAL UNIV
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