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A kind of traditional Chinese medicine composition that alleviates the stimulation of epoxyethanol and polyhydric alcohol

A technology of epoxy ethanol and polyols, which can be used in pharmaceutical formulations, skin care preparations, medical preparations containing active ingredients, etc., can solve the problems of low irritation and risk of irritation, and achieve the effect of reducing the amount of use

Active Publication Date: 2019-02-26
BEIJING DONGFANG MIAOSEN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the patent does not provide test data to prove that the composition has low irritation and contains a variety of polyols, which may pose a risk of irritation

Method used

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  • A kind of traditional Chinese medicine composition that alleviates the stimulation of epoxyethanol and polyhydric alcohol
  • A kind of traditional Chinese medicine composition that alleviates the stimulation of epoxyethanol and polyhydric alcohol
  • A kind of traditional Chinese medicine composition that alleviates the stimulation of epoxyethanol and polyhydric alcohol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Take the following raw materials in parts by weight: 60 parts of Sophora flavescens, 15 parts of Fangfeng, 15 parts of Tribulus terrestris, 3 parts of Hovenia dulcis, and mix well to obtain material 1;

[0037] (2) Mix the material 1 obtained in step (1) with 30% ethanol solution, the mass volume ratio of material 1 and ethanol solution is 1:30, heat and reflux at 80°C for 1h, then cool to below 30°C, vacuum pump Filter, collect filtrate, obtain material 2;

[0038] (3) Pour the material 2 obtained in step (2) into a rotary evaporator, and rotatively evaporate all the ethanol at 55° C. to obtain a plant extract, which is material 3;

[0039](4) Add 1,3-butanediol to the material 3 obtained in step (3) to redissolve, the mass ratio of material 3 to 1,3-butanediol is 1:15, cool to below 30°C, and vacuum Filter, collect filtrate, obtain material 4;

[0040] (5) The material 4 obtained in step (4) is heated and sterilized in a water bath, sterilized at 90° C. for 40 m...

Embodiment 2

[0042] (1) Take the following raw materials in parts by weight: 40 parts of Sophora flavescens, 20 parts of Fangfeng, 15 parts of Tribulus terrestris, 8 parts of Hovenia dulcis, and mix well to obtain material 1;

[0043] (2) Mix material 1 obtained in step (1) with 50% ethanol solution, the mass volume ratio of material 1 and ethanol solution is 1:80, heat and reflux at 80°C for 1.5h, then cool to below 30°C, vacuum Suction filtration, collect filtrate, obtain material 2;

[0044] (3) Pour the material 2 obtained in step (2) into a rotary steamer, and steam all the ethanol at 60° C. to obtain a plant extract, which is material 3;

[0045] (4) Add 1,3-butanediol to the material 3 obtained in step (3) to redissolve, the mass ratio of material 3 to 1,3-butanediol is 1:30, cool to below 30°C, and vacuum Filter, collect filtrate, obtain material 4;

[0046] (5) The material 4 obtained in step (4) is heated and sterilized in a water bath, sterilized at 85° C. for 40 minutes, and ...

Embodiment 3

[0048] (1) Take the following raw materials in parts by weight: 25 parts of Sophora flavescens, 25 parts of Fangfeng, 20 parts of Tribulus terrestris, 10 parts of Hovenia dulcis, and mix well to obtain material 1;

[0049] (2) Mix material 1 obtained in step (1) with 90% ethanol solution, the mass volume ratio of material 1 and ethanol solution is 1:30, heat and reflux at 85°C for extraction for 2h, then cool to below 30°C, and vacuum pump Filter, collect filtrate, obtain material 2;

[0050] (3) Pour the material 2 obtained in step (2) into a rotary steamer, and steam all the ethanol at 60° C. to obtain a plant extract, which is material 3;

[0051] (4) Add 1,3-butanediol to the material 3 obtained in step (3) to redissolve, the mass ratio of material 3 to 1,3-butanediol is 1:30, cool to below 30°C, and vacuum Filter, collect filtrate, obtain material 4;

[0052] (5) The material 4 obtained in step (4) is heated and sterilized in a water bath, sterilized at 90° C. for 40 mi...

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Abstract

The invention provides a traditional Chinese medicine composition for relieving irritation of epoxy ethanol and polyhydric alcohols. The traditional Chinese medicine composition comprises the following raw material medicines: radix sophorae flavescentis, radix saposhnikoviae, tribulus terrestris and hovenia dulcis. The invention further provides a corresponding preparation method. The preparationmethod comprises the following steps: mixing the four raw materials according to a ratio, and carrying out methods of extraction, filtration and redissolving, thereby obtaining the traditional Chinesemedicine composition which is capable of effectively relieving adverse reactions of skin affected by phenoxyethanol and polyhydric alcohol substances. Due to scientific matching of the four components, namely the radix sophorae flavescentis, the radix saposhnikoviae, the tribulus terrestris and the hovenia dulcis, the traditional Chinese medicine composition is capable of remarkably reducing burning heat sensation and pricking caused by preservatives (such as phenoxyethanol) and polyhydric alcohol substances (such as pentanediol, hexanediol and octylene glycol) in cosmetics upon skin, and hasa synergetic preservation effect on phenoxyethanol, thereby reducing the amount of the phenoxyethanol preservative to the maximum extent.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for alleviating the stimulation of epoxyethanol and polyhydric alcohol. Background technique [0002] In recent years, as international and domestic preservative regulations have become more and more stringent, fewer and fewer preservatives can be used in cosmetics. Phenoxyethanol (PE), as a non-formaldehyde releaser, has become the choice of many brands . According to incomplete statistics from a third party, phenoxyethanol is the second most commonly used preservative, accounting for more than 1 / 3 of it. However, when the amount of phenoxyethanol added in cosmetics exceeds a certain ratio, it will cause uncomfortable skin reactions, such as stinging and burning, especially when it acts on sensitive skin. Its mechanism of action is that phenoxyethanol can activate TRPV1 channels on skin cells, thereby causing people to fee...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61K8/49A61K8/34A61Q19/00
CPCA61K8/34A61K8/345A61K8/4906A61K8/97A61K2800/10A61K2800/524A61Q19/00
Inventor 董银卯刘有停孟宏刘宇红马来记查沛娜
Owner BEIJING DONGFANG MIAOSEN BIOTECH CO LTD
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