Application of nicotinamide (NAM) to preparation of drugs used for preventing and treating diabetic nephropathy and regulating blood pressure

A technology for diabetic nephropathy and nicotinamide is applied in the field of compounds to achieve the effects of reducing oxidative stress, improving kidney disease and reducing fibrosis

Inactive Publication Date: 2018-07-06
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there have been no relevant reports on the role of NAM in protecting diabetic nephropathy and regulating blood pressure at home and abroad.

Method used

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  • Application of nicotinamide (NAM) to preparation of drugs used for preventing and treating diabetic nephropathy and regulating blood pressure
  • Application of nicotinamide (NAM) to preparation of drugs used for preventing and treating diabetic nephropathy and regulating blood pressure
  • Application of nicotinamide (NAM) to preparation of drugs used for preventing and treating diabetic nephropathy and regulating blood pressure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 In vivo experiment

[0036] Establish an animal intervention model:

[0037] Mice feeding: Ins-Akita and WT-Akita mice born in the same cage are reared in an animal room with a room temperature of 22°C and a relative humidity of 55% at SPF level. They are fed with common rodent diet and free to eat and drink;

[0038] Mice intervention: After 2 weeks of adaptive feeding, Ins-Akita mice were randomly divided into saline intervention group (Ins2-Akita+NS group, n=6, 0.1ml / 10g body weight, intraperitoneal injection) and NAM intervention group ( Ins2-Akita+NAM group, 10mg / Kg / d, n=12, intraperitoneal injection); a total of 6 weeks of intervention;

[0039] Animal monitoring: The body weight and fasting blood glucose of the three groups of mice were measured one week before the intervention and every week after the intervention. The blood pressure (tail pressure meter) was measured one week before execution, and the systolic and diastolic blood pressure were measured, and ...

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Abstract

The invention relates to the medicinal application of NAM, specifically to application of NAM to preparation of drugs used for preventing and treating diabetic nephropathy and regulating blood pressure, belonging to the field of compounds. The experimental results of intervention of NAM in type 2 diabetes model mice prove NAM has obvious protective effect on diabetic kidneys and can alleviate therenal fibrosis, inflammations and oxidative stress in diabetic mice, and the protection effect is achieved independent of blood sugar reduction and weight improvement. Further, NAM can be used for preparing drugs for preventing and treating diabetic nephropathy and regulating blood pressure. The application of NAM in the invention provides a novel target and a novel idea for clinical prevention and treatment of diabetic nephropathy and improvement of renal lesions, and further proves that the improvement of renal oxidative stress plays an important role in the prevention and treatment of diabetic nephropathy.

Description

Technical field [0001] The invention belongs to the field of compounds, and relates to a new medicinal use of the compound nicotinamide (NAM), and specifically relates to the use of nicotinamide (NAM) in the preparation of drugs for the prevention and treatment of diabetic nephropathy and blood pressure regulation. Background technique [0002] Data show that diabetes is currently one of the main chronic non-communicable diseases affecting health, and the prevalence of type 2 diabetes among adults in my country has reached 11.6%. Studies have shown that long-term hyperglycemia can cause macrovascular and microvascular complications, including cardiovascular and cerebrovascular diseases, peripheral neuropathy, retinopathy, and kidney disease, among which diabetic nephropathy is one of the main complications. According to statistics, diabetic nephropathy is the first cause of uremia in European and American countries, and the second cause of uremia in my country. The disease not on...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/455A61P3/10A61P13/12A61P9/12
CPCA61K31/455
Inventor 张朝云杨叶萍郭诗哲
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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