Application of the reagent for detecting the expression of g protein-coupled receptor 18 in the preparation of reagents for sepsis diagnosis, disease course monitoring and prognosis judgment

Abstract

The invention discloses the application of a reagent for detecting the expression of G protein-coupled receptor 18 in the preparation of sepsis diagnosis, disease course monitoring and prognosis judgment reagents, and confirms the expression level of G protein-coupled receptor 18 on the surface of sepsis neutrophils down. Apply the method of detecting G protein-coupled receptor 18 on the surface of neutrophils in peripheral blood to the diagnosis of sepsis and severe bacterial infection, especially the first discovery that the lower the expression of G protein-coupled receptor 18 on the surface of neutrophils, the lower the expression of sepsis and severe bacterial infection The more severe the multiple organ damage in patients with bacterial infection, the worse the prognosis. This provides a more convenient, sensitive, rapid and stable way for clinical diagnosis of patients or animals with sepsis or severe bacterial infection, and monitoring of disease progression.

Description

technical field [0001] The invention relates to the technical fields of biomedicine and disease diagnosis, in particular to the application of a reagent for detecting G protein-coupled receptor 18 in the preparation of reagents for sepsis diagnosis, disease course monitoring and prognosis judgment. Background technique [0002] Sepsis or septic shock is a common clinical critical illness. At present, despite the rapid development of medicine, sepsis is still a world-class problem. G protein-coupled receptor 18 is expressed in various cells and tissues in the human body. As a cell surface receptor, it can be activated by a variety of ligands, such as anandamide, arachidylglycine, cannabinoids, resolvin, etc., and participates in the regulation of reproduction, immunity, metabolism and nervous system. The latest research shows that G protein-coupled receptor 18 plays an important role in the regulation of inflammatory response in sepsis. G protein-coupled receptor 18 gene kno...

AI Technical Summary

Problems solved by technology

However, bacteriological methods have the disadvantages of time-consuming and false positives, which have great limitations on timely diagnosis and medication, and in vitro culture cannot reflect the severity of bacterial infection

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