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Traditional Chinese medicine composition for secondary prevention of qi deficiency and blood stasis syndrome myocardial infarction

A technique for myocardial infarction, qi deficiency and blood stasis, which is applied in the field of traditional Chinese medicine and can solve problems such as no report on the effect of myocardial infarction.

Inactive Publication Date: 2018-06-22
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Chinese patent CN101647856B discloses a pharmaceutical composition whose active ingredients are made of astragalus, salvia miltiorrhiza, and leech, and discloses the curative effect of the pharmaceutical composition for treating coronary heart disease, and the pharmaceutical composition is used for qi deficiency and blood stasis syndrome myocardial infarction II The effect of secondary prevention has not been reported
In addition, anti-heart failure and anti-arrhythmia are the key factors for the secondary prevention of myocardial infarction. The improvement effect of ventricular arrhythmia in the recovery period after infarction has not been reported
However, this medicinal composition also uses astragalus-type warm-dryness traditional Chinese medicine, and there is no Yin-nourishing traditional Chinese medicine in the prescription. It can be predicted that long-term use of this prescription will cause patients to be prone to dry-heat symptoms such as upset and poor sleep.

Method used

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  • Traditional Chinese medicine composition for secondary prevention of qi deficiency and blood stasis syndrome myocardial infarction
  • Traditional Chinese medicine composition for secondary prevention of qi deficiency and blood stasis syndrome myocardial infarction
  • Traditional Chinese medicine composition for secondary prevention of qi deficiency and blood stasis syndrome myocardial infarction

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Experimental program
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Effect test

Embodiment 1

[0078] Prescription: Astragalus 30 parts, Danshen 15 parts, Ophiopogon japonicus 30 parts and leeches 3 parts.

[0079] Preparation:

[0080] (1) Take the leech according to the proportioning ratio, wash, dry, pulverize, and sieve to obtain the leech fine powder;

[0081] (2) Weigh astragalus, salvia miltiorrhiza and Radix Ophiopogon japonicus according to the proportion, add 10 times the total weight of the three raw materials and reflux extract 3 times, each time for 2 hours, combine the extracts, filter, and concentrate the filtrate under reduced pressure to the original filtrate 1 / 10 of the volume to obtain a concentrated solution;

[0082] (3) Add ethanol to the concentrated solution until the alcohol content is 60%, leave it to settle at 4°C for 24 hours, filter, and after the filtrate is decompressed to recover ethanol, it is concentrated under reduced pressure into a thick extract with a water content of 15-20%, and the steps (1) The leech fine powder is mixed evenly...

Embodiment 2

[0084] Prescription: Astragalus 20 parts, Danshen 30 parts, Ophiopogon japonicus 20 parts and leech 5 parts.

[0085] Preparation:

[0086] (1) Take the leech according to the proportioning ratio, wash, dry, pulverize, and sieve to obtain the leech fine powder;

[0087] (2) Take Radix Astragali, Salvia Miltiorrhiza and Ophiopogon japonicus in proportion, add 5 times of the total weight of three kinds of crude drugs, and the volume fraction is 70% ethanol reflux extraction 3 times, each 2 hours, merge extract, filter, filtrate reduces After recovering the ethanol, concentrate under reduced pressure to form a thick extract with a water content of 15-20%, mix with the leech fine powder described in step (1), add polyethylene glycol, etc. and mix evenly as the content, gelatin, glycerin, etc. Add water to dissolve as glue, and make soft capsules according to conventional methods.

Embodiment 3

[0089] Prescription: 10 parts of Astragalus, 10 parts of Danshen, 10 parts of Ophiopogon japonicus and 3 parts of leeches.

[0090] Preparation method: weigh astragalus, salvia miltiorrhiza, Ophiopogon japonicus and leeches according to the proportion, wash, dry, pulverize and sieve respectively to obtain fine powder of medicinal materials, mix them and pack them into powders.

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Abstract

The invention discloses a traditional Chinese medicine composition for secondary prevention of qi deficiency and blood stasis syndrome myocardial infarction. The composition is prepared from, by weight, 5-60 parts of astragalus membranaceus, 5-40 parts of radix salviae miltiorrhizae, 5-60 parts of radix ophiopogonis and 3-10 parts of leeches. The components of the traditional Chinese medicine composition have a synergistic effect, and all the medicines are combined in a specified proportion so as to achieve the effects of tonifying qi and promoting blood circulation, nourishing the heart and protecting veins; the composition has remarkable treatment and prevention effects on atherosclerosis, myocardial remodelling after myocardial infarction, ventricular arrhythmia, qi deficiency and bloodstasis type heart failures and the like, is suitable for secondary prevention of myocardial infarction, and is especially suitable for prognosis of myocardial infarction patients with qi and yin deficiency and blood stasis syndrome. The traditional Chinese medicine composition is high in safety, small in side effect and suitable for being taken for a long time.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for secondary prevention of myocardial infarction with qi deficiency and blood stasis syndrome. Background technique [0002] Cardiovascular disease is currently the leading cause of death in the world. In recent years, the morbidity and mortality of myocardial infarction among urban and rural residents in my country are still on the rise, and tend to be younger. The persistence of various risk factors related to myocardial infarction is the key to the high mortality and disability rates after myocardial infarction. Therefore, it is imminent to actively do a good job in secondary prevention. Secondary prevention of myocardial infarction refers to preventing re-infarction and sudden death after myocardial infarction, and improving the quality of life of patients. The measures mainly include non-drug treat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P9/10A61P9/00A61K35/62
CPCA61K35/62A61K36/481A61K36/537A61K36/8968A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 张敏州马世玉丘小惠郭力恒白俊其周袁申黄娟
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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