Preventative therapy for post-traumatic osteoarthritis

Abstract

The invention provides compositions. The compositions comprise a reverse-temperature sensitive hydrogel comprising a biopolymer such as a polysaccharide and a synthetic polymer, and a compound in an amount that reversibly inhibits respiratory enzyme complex I, and methods of using the composition, are provided.

Description

[0001] priority claim [0002] This application claims priority to US Provisional Patent Application No. 62 / 207,059, filed August 19, 2015, the disclosure of which is incorporated herein by reference. [0003] Statement of Government Rights [0004] This invention was made with Government support under Grant No. W81XWH-11-1-0583 awarded by the Department of Defense. The government has certain rights in this invention. Background technique [0005] Most older adults are familiar with the pain, immobility, and general disability associated with osteoarthritis. Post-traumatic osteoarthritis (PTOA) is an acutely accelerated form of arthritis associated with traumatic damage to the articular surfaces of a joint, resulting in a well-received joint replacement procedure considered common in orthopedic medicine in patients. Candidates had previously caused substantial disease progression. Because patients are often injured at a relatively young age and there are currently no vi...

AI Technical Summary

Problems solved by technology

As with any surgery, there can be surgical complications such as infection and damage to surrounding structures, blood clots, heart attack, and stroke, and the implant will eventually wear out or loosen

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