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Novel application of rapid immunodetection system to operation

A detection system and rapid immunization technology, applied in measuring devices, biological testing, material inspection products, etc., can solve the problems of time-consuming, unsatisfactory instant convenience, complicated operation, etc., and achieve the effect of convenient operation

Pending Publication Date: 2018-05-29
GUANGZHOU KANGRUN BIOTECHNOLOGY CO LTD
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  • Abstract
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  • Application Information

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Problems solved by technology

This processing method not only takes a lot of time, but also is complicated to operate, which cannot meet the immediate and convenient needs.
[0008] At present, the gold standard for judging whether cervical lymph node metastasis of thyroid cancer is intraoperative rapid pathological section requires relevant pathological professional technicians, experienced pathologists and expensive fine equipment. Routine examination takes about 40 minutes

Method used

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  • Novel application of rapid immunodetection system to operation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] As a new application in surgery, a rapid immunoassay system is used to identify whether thyroid cancer has cervical lymph node metastasis by detecting the content of thyroglobulin.

[0034] The three-dimensional structure of thyroglobulin Tg as figure 1 As shown, thyroglobulin is an iodized glycoprotein in thyroid tissue, which is a homodimer with a molecular mass of about 660kDa. The subunits of human thyroglobulin consist of 2767 amino acid residues. The biological half-life of Tg in vivo is 65.2 hours. By detecting the thyroglobulin Tg content in regional lymph node tissue to determine whether there is cervical lymph node metastasis of thyroid cancer, it can provide a basis for decision-making of neck lymph node dissection.

[0035] The rapid immunoassay system adopted in this embodiment is composed of Tg test paper and detector, such as figure 2 shown.

[0036] Tg test paper, which tests and displays the content of tissue thyroglobulin Tg, and a positive detect...

Embodiment 2

[0052] A rapid immunoassay system as a new application in surgery, other features are the same as in Example 1, the difference is that step d specifically compares the TG value in the eluate with the TG detection base value in the blood at the same time, When the ratio is greater than 1, it is determined that there is regional lymph node metastasis of thyroid cancer. Simultaneous blood refers to the blood of the same subject at the same time.

[0053] The basic value in the blood is obtained by dripping the blood or the processed blood sample onto the detection TG test paper, and then scanning the detection line and quality control line on the TG test paper through the detector of the immunoassay system, and passing through the processing set inside the detector. The unit obtains the TG content in blood or a processed sample of blood.

[0054] The basic value of TG detection in blood can be obtained by detecting the blood collected on the spot or by detecting the blood collec...

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Abstract

The invention discloses novel application of a rapid immunodetection system to an operation. According to the novel application of the rapid immunodetection system to the operation, whether cervical lymph node metastasis of thyroid cancer exists or not is identified by detecting the content of thyroglobulin. The novel application of the rapid immunodetection system in the operation comprises the following specific operation steps that a, tissues of regional lymph nodes of a thyroid are punctured; b, an eluent for puncturing the tissues is prepared; c, quantitative detection treatment of the thyroglobulin (TG) is directly carried out on the prepared eluent through the rapid immunodetection system; and d, whether thyroid cancer metastasis of the regional lymph nodes exists or not is identified according to the TG detection result obtained by the rapid immunodetection system, wherein in the step c, the eluent is dripped to TG test paper, then the detection line and the quality control line on the TG test paper are scanned through a detector of the immunodetection system, and parameter calculation treatment is carried out through a processing unit arranged inside the detector so as toobtain the content of the thyroglobulin (TG) in the tissues. The novel application of the rapid immunodetection system to the operation has the characteristics of being convenient and rapid to operate, and operation can be directly performed beside an operating table during operation.

Description

technical field [0001] The invention relates to the technical field of medical equipment, in particular to a new application of a rapid immune detection system in surgery. Background technique [0002] Thyroglobulin Tg is a macromolecular glycoprotein secreted by thyroid follicular epithelium, which often exists in normal thyroid tissue, well-differentiated thyroid cancer tissue and metastatic lymph nodes, and the concentration in interstitial fluid is much higher than that in serum, so differentiation During postoperative follow-up of type thyroid cancer, if a high concentration of Tg is detected in the extrathyroid tissue, the possibility of thyroid cancer metastasis should be highly alerted. [0003] FNA-Tg (FNA fine-needle aspiration Tg value) detection technology was first reported by Pacini et al. in 1992. It is easy to operate, accurate, and can avoid the subjectivity of pathological diagnosis to a certain extent. It has been widely used in clinical practice. Accurat...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N33/574
CPCG01N33/574G01N33/6893G01N2800/50
Inventor 杨洪黄文喜杨胤瑾
Owner GUANGZHOU KANGRUN BIOTECHNOLOGY CO LTD
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