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Kit for screening susceptible gene of atrial fibrillation disease

A susceptibility gene, atrial fibrillation technology, applied in the field of medicine and molecular biology, to improve the survival rate and early detection rate

Inactive Publication Date: 2018-05-01
HUBEI UNIV OF TECH
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  • Summary
  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

[0005] At present, there is still no effective early diagnosis and treatment for patients with atrial fibrillation. However, the mortality rate of atrial fibrillation is extremely high. treatment to improve the survival rate of the disease

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] (1) 85 patients with atrial fibrillation were selected, and 2 mL of venous blood was drawn from the patients to extract DNA.

[0017] (2) The 18 genes that cause familial atrial fibrillation were fully sequenced in these patients by the method of next generation sequencing.

[0018] (3) A total of 87 non-synonymous sites were found in the sequencing results. In order to determine whether these sites were mutations, the database was compared with the dbSNP single nucleotide polymorphism database of the NCBI National Center for Biotechnology Information and the 1000genomes project database. For comparison, at the same time, 260 Chinese adults from the Thousand Genomes database were used as the same-race control group, and the carrying rates of these loci in the database and the control group were calculated, compared with the carrying rates in the case cohort, and the p-value was calculated.

[0019] (4) According to information biology technology, use the existing softwa...

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Abstract

The invention discloses a kit for screening susceptible gene of atrial fibrillation disease, and belongs to the technical fields of medicine and molecular biology. The kit comprises the following detection gene: KCNQ1, SCN5A and KCNJ2, and comprises reagents for performing whole exome sequencing on KCNQ1, SCN5A and KCNJ2. By performing whole exome sequencing on KCNQ1, SCN5A and KCNJ2 of a subject,whether the subject carries mutation sites is found, so that the atrial fibrillation disease is determined. The kit screens sporadic atrial fibrillation virulence gene in a crowd, and effectively improves the early detection rate of fibrillation disease, thereby realizing early treatment, reducing the burden of patients, and providing reference for the medication of patients with atrial fibrillation.

Description

technical field [0001] The invention relates to the fields of medicine and molecular biology, in particular to a screening kit for susceptibility genes of atrial fibrillation disease. Background technique [0002] Atrial fibrillation (AF) is one of the most common arrhythmia diseases clinically, and is an independent risk factor for various cardiovascular diseases. Serious consequences such as tachycardia, ventricular arrhythmia and even death are extremely harmful to public health. [0003] With the development of molecular medicine, atrial fibrillation is considered to be the result of the joint action of genetic factors and environmental factors. Although the control of environmental factors can delay the onset and prognosis of atrial fibrillation to a certain extent, the lack of understanding of inherent genetic factors has greatly hindered the research and judgment of atrial fibrillation. [0004] Studies in recent years have shown that multiple molecular markers, suc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/156
Inventor 黄渊唐景峰陈兴珍周策凡
Owner HUBEI UNIV OF TECH
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