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Application of sunflower small molecule peptide in reduction of uric acid, dissolving of uratoma and repairing of renal function

A small molecule peptide and tophi technology, applied in the field of medicine, can solve the problems of not exerting economic benefits and medical effects, waste of resources, etc., and achieve a good repair effect, dissolve sodium urate, and relieve pain and blood uric acid.

Pending Publication Date: 2018-04-27
吉林省倍减生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in traditional applications, the sunflower tray after removing sunflower seeds is usually used as livestock feed to feed livestock or as a burning material for heating and cooking, which has not brought into play its greater economic benefits and medical effects, resulting in waste of resources

Method used

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  • Application of sunflower small molecule peptide in reduction of uric acid, dissolving of uratoma and repairing of renal function
  • Application of sunflower small molecule peptide in reduction of uric acid, dissolving of uratoma and repairing of renal function
  • Application of sunflower small molecule peptide in reduction of uric acid, dissolving of uratoma and repairing of renal function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation of embodiment 1 sunflower small molecule peptide

[0022] 1) Crush 5 kg of sunflower discs to 100 mesh, add 30 kg of deionized water, stir thoroughly, adjust the pH value to 8 with sodium hydroxide, and stir at 45° C. for 120 minutes to obtain a sunflower disc isolated protein solution.

[0023] 2) Heat the sunflower dish protein separation solution to 85°C, stir for 1 hour, cool to 45°C, add compound protease (ginger protease, snail protease, bat moth larvae protein digestion enzyme) accounting for 0.1% of the total volume of the sunflower dish protein separation solution : 0.5:1 mass ratio), enzymatic hydrolysis for 3 hours, when the reaction was terminated, the temperature was raised to 85°C within 5 minutes, and kept for 5 minutes to inactivate the complex protease, and the obtained enzymatic hydrolyzate was used for future use.

[0024] 3) Centrifuge the enzymolysis solution in step 2) at a speed of 5000 rpm for 8 minutes, collect the supernatant, a...

Embodiment 2

[0029] Example 2 Sunflower Small Molecular Peptide Lowering Uric Acid and Repairing Damaged Kidney Cell Test

[0030] (1) Material

[0031] Small molecular peptide: the sunflower small molecular peptide prepared in Example 1.

[0032] Yeast paste: British Oxiod company.

[0033] Oxonic acid potassium salt: Sigma Company, USA, batch number: 101310713.

[0034] Allopurinol tablets: Shimao Tianjie Pharmaceutical (Jiangsu) Co., Ltd., batch number: 201608301.

[0035] Mouse uric acid detection kit: Nanjing Jiancheng Institute of Bioengineering.

[0036] SPF grade KM mice: male, body weight (22-25) g, provided by the Experimental Animal Center of the First Hospital of Jilin University.

[0037] (2) Modeling and drug administration

[0038] The mice were weighed before the study, 12 of them were used as the blank control group, and the rest were used as the hyperuricemia model group. Weighing was performed every morning during the experiment. In this modeling experiment, the m...

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Abstract

The invention discloses application of sunflower small molecule peptide in reduction of uric acid, dissolving of uratoma and repairing of a renal function. According to the application of sunflower small molecule peptide in preparation of drugs for reduction of uric acid, dissolving of uratoma and repairing of the renal function, the sunflower small molecule peptide can have effects of diminishinginflammation, subduing swelling, stopping pain and reducing blood uric acid, and dissolving sodium urate, meanwhile, good effect of repairing injured cells of the kidneys is achieved, the sunflower small molecule peptide has effect of treating both symptoms and root causes of hyperuricosuria, and thus, the hyperuricosuria can be treated fundamentally.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the application of a sunflower small molecule peptide in the preparation of medicines for reducing uric acid, dissolving tophi and repairing kidney function. Background technique [0002] Gout is a metabolic disease caused by purine metabolism disorder. The blood uric acid concentration rises, and sodium urate crystals are deposited in the bone joints, arteries, and vertebral spaces of the lower limbs. , severe cases showed joint deformity and dysfunction, and has the characteristics of recurrent attacks. The existence of gout can also lead to the exacerbation of coronary heart disease, diabetes, hypertension and other diseases. In terms of treatment, there is no radical cure for gout with Western medicine. Although colchicine, non-steroidal anti-inflammatory drugs, and allopurinol can relieve symptoms and lower blood uric acid, their effects are relatively single, and it is d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/01A61P19/06A61P13/12
CPCA61K38/011
Inventor 刘小波杨茂义赵国安宋海淼葛振龙康明李婉男高波韩露
Owner 吉林省倍减生物科技有限公司
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