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A prism-type surface plasmon resonance spectrometer angle modulation mechanism

A technology of surface plasmon and angle modulation, which is applied in the direction of instruments, scientific instruments, measuring devices, etc., can solve the problems of not being able to obtain a large refractive index detection range, and cannot provide SPR scanning with a large angle range, so as to avoid light scattering and deformation, Effect of reducing light energy loss and cost reduction

Active Publication Date: 2020-05-15
丁利 +4
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0003] However, the existing prism-based SPR systems cannot provide SPR scanning with a large angle range, and thus cannot obtain a large refractive index detection range, so that the surface plasmon resonance spectrometer can only meet a small range of applications

Method used

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  • A prism-type surface plasmon resonance spectrometer angle modulation mechanism
  • A prism-type surface plasmon resonance spectrometer angle modulation mechanism
  • A prism-type surface plasmon resonance spectrometer angle modulation mechanism

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Embodiment Construction

[0030] The structure of the angle modulation mechanism of the prism-type surface plasmon resonance spectrometer of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0031] see figure 1 and figure 2 One embodiment of the invention is shown. As shown in the figure, the prism-type surface plasmon resonance spectrometer angle modulation mechanism of the present invention includes a fixed mount 1 and a synchronous rotating mechanism 2, first and second transmission mechanisms 9 and 12, a chip 3 ( In this embodiment, an integrated prism chip 23 ), a flow cell (not shown in the figure), a wedge-shaped light emitting end 4 , a CCD receiving end 5 , a pressing mechanism 6 and two rotating arms 10 are used.

[0032] The synchronous rotation mechanism 2 drives the two rotation arms 10 to rotate synchronously under the action of the first transmission mechanism 9 . The wedge-shaped light emitting end 4 and the CCD receiving end 5 ...

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Abstract

The invention discloses a prism-type surface plasmon resonance spectrometer angle modulation mechanism. The mechanism comprises a fixing frame, a synchronous rotation mechanism installed on the fixingframe, first and second transmission mechanisms, an integrated prism chip, a flow cell, a wedge-shaped light transmitting end, a CCD receiving end, a compressing mechanism and two rotation arms. Thesynchronous rotation mechanism drives the two rotation arms to synchronously rotate under action of the first transmission mechanism. The wedge-shaped light transmitting end and the CCD receiving endare respectively fixed on one rotation arm and can rotate along with the rotation arm. The extension lines of the rotation shafts of the two rotation arms are located in the center of the top surfaceof the integrated prism chip. The wedge-shaped light transmitting end emits a wedge-shaped light beam to the center of the integrated prism chip and the reflected wedge-shaped light beam irradiates CCD of the CCD receiving end. The compressing mechanism can move downward under the action of the second transmission mechanism to compress the chip and the flow cell. The mechanism can accurately and fast adjust an angle and has a large adjustment range.

Description

technical field [0001] The invention relates to the field of surface plasmon resonance spectrometers, in particular to a prism-type surface plasmon resonance spectrometer angle modulation mechanism. Background technique [0002] Surface plasmon resonance spectrometer (Surface Plasmon Resonance, SPR) is a biosensing instrument that appeared in the 1980s, and is the product of the combination of modern physics, biology and analytical chemistry. Surface plasmon resonance spectrometer is generally favored by large foreign instrument companies due to its advantages of simplicity, rapidity, and high sensitivity. After large-scale research and development, it has developed into a powerful tool for qualitative or quantitative measurement of molecular interactions. The attention and attention of pharmaceutical companies has been widely used in many fields such as biotechnology, medical testing, environmental science, food safety, drug screening, and material analysis. There are main...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/01G01N21/55
CPCG01N21/01G01N21/55
Inventor 丁利苏荣欣李洪增王利兵梅丹阳
Owner 丁利
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