Microfluidic chip and application thereof
A microfluidic chip and microchannel technology, applied in the field of microfluidics, can solve the problems of single nephron structure and cannot effectively simulate blood purification, etc., and achieve the effect of easy maintenance.
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Embodiment 1
[0020] Take the nephron chip to detect the polar toxicity of different concentrations of cisplatin on nephron cells as an example, as shown in the attached image 3As shown, 0μg / ml, 3μg / ml, 10μg / ml, and 30μg / ml cisplatin were added to the blood pole inlet. After 24 hours, it can be observed that when 30μg / ml cisplatin is added to the system, the glomerular vascular endothelial cells , renal podocytes, renal tubular epithelial cell activity decreased significantly, indicating that 30μg / ml cisplatin has obvious toxicity to glomerular vascular endothelial cells, renal podocytes, and renal tubular epithelial cells.
Embodiment 2
[0022] Take the nephron chip to detect the polar toxicity of doxorubicin at 1.25 μg / ml to nephron cells as an example, as shown in the attached Figure 4 As shown, after adding 1.25 μg / ml doxorubicin at the blood pole inlet, after 48 hours, it can be observed that the activity of glomerular vascular endothelial cells, renal podocytes, and peritube vascular endothelial cells decreased significantly, indicating that in 48 hours , 1.25μg / ml doxorubicin has obvious toxicity to glomerular vascular endothelial cells, renal podocytes and peritubular vascular endothelial cells, but has little effect on renal tubular epithelial cells.
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