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A kind of medical nanofiber reinforced composite material and preparation method thereof

A technology of composite materials and nanofibers, which is applied in the field of medical nanofiber-reinforced composite materials and its preparation, which can solve the difficulty of meeting the requirements of mechanical properties and biodegradability of materials, composition ratio, segment distribution, and difficult stable control of molecular weight , can not fully meet the clinical needs of medical polymer materials, etc., to achieve good biodegradability, good biocompatibility, and enhanced mechanical properties

Active Publication Date: 2020-02-28
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0003] Medical materials prepared from single-component polymer raw materials have high elongation at break, good flexibility, and little damage to blood vessels and other tissues, but they also have the following shortcomings, such as slow degradation speed, poor tensile strength, and falling off. It takes 1 to 2 months, and it takes more than 6 months for complete absorption. In clinical practice, the closure time of blood vessels and other tubular tissues is only 1 to 2 weeks. There are potential risks in the long-term use of medical materials in the human body. In addition, blood vessels or other tissues may still Phenomena such as damage and bleeding are not conducive to the recovery of patients; while simple grafting or copolymerization of two materials is used, the composition ratio, segment distribution, molecular weight, etc. are not easy to control stably, and the mechanical properties and biodegradability of the material are very low. It is difficult to meet the requirements at the same time, so it cannot fully meet the clinical needs of medical polymer materials

Method used

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  • A kind of medical nanofiber reinforced composite material and preparation method thereof

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preparation example Construction

[0032] The present invention also includes a preparation method of medical nanofiber-reinforced composite material, comprising the following steps:

[0033] ① Vacuum-dry the polyester material at 100°C for 24 hours. Under the protection of nitrogen, put it in the screw of the spinning device to melt it. Under the voltage of 8~30KV, extrude and spin the filament at a constant speed. After receiving it in the vortex cooling liquid tank, the diameter 1-10 μm polyester fiber bundle; the polyester material is polyglycolide or polylactide;

[0034] ②Under the protection of nitrogen, heat-stretch the polyester fiber bundle obtained in step ① twice, each stretching ratio is 5-8 times, to obtain nanofibers with a diameter of 200-800nm;

[0035] When the material of the polyester fiber bundle obtained in step 1 is polyglycolide, the temperatures of the two thermal stretches are respectively 180°C and 160°C; The stretching temperatures are 150°C and 130°C respectively;

[0036] ③ The n...

Embodiment 1

[0049] A medical nanofiber-reinforced composite material, the composite material is composed of basic materials and short nanofibers, the short nanofibers maintain a crystalline form and are uniformly dispersed in the basic material, and the mass percentage of short nanofibers in the composite material is 10%; The base material is polydioxanone; the nano-short fiber is a polyester material, and the polyester material is polyglycolide; the diameter of the nano-short fiber is 200 nm, and the length is 10 μm.

Embodiment 2

[0051] A medical nanofiber-reinforced composite material, the composite material is composed of base material and nano-short fibers, the nano-short fibers maintain a crystalline form and are uniformly dispersed in the base material, and the mass percentage of nano-short fibers in the composite material is 50%; The base material is polytrimethylene carbonate; the nano-short fiber is a polyester material, and the polyester material is polylactide; the diameter of the nano-short fiber is 800 nm, and the length is 100 μm.

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Abstract

A medical nanofiber-reinforced composite material, the composite material is composed of basic materials and short nanofibers, the short nanofibers maintain a crystalline form and are uniformly dispersed in the basic material, and the mass percentage of short nanofibers in the composite material is 1% to 50% %. The advantages of this composite material are that the single-component polymer material has high elongation at break, good flexibility, little damage to blood vessels and other tissues, and can maintain good tensile strength and elongation at break in human tissues, and The tensile strength of the material can be greatly improved; the medical nanofiber reinforced composite material of the invention has good biocompatibility and biodegradability, and can meet the clinical requirements of medical materials.

Description

technical field [0001] The invention relates to the technical field of nanofiber composite materials, in particular to a medical nanofiber reinforced composite material and a preparation method thereof. Background technique [0002] Various tissues and organs in the human body may be abnormal or damaged. At present, the transplantation of tissues and organs is mainly used to restore their functions. In this process, a large amount of biological materials are needed to support the normal work of tissues and organs, such as stents, Ligation clips, etc., materials with good biocompatibility and biodegradability can finally form new functional tissues with the further proliferation and differentiation of cells and the degradation and absorption of materials to achieve the purpose of repairing defective tissues. The demand in the market is also increasing. [0003] Medical materials prepared from single-component polymer raw materials have high elongation at break, good flexibil...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L67/04C08L69/00C08J5/04
CPCC08J5/046C08J2367/04C08J2369/00C08J2467/04
Inventor 刘阳王宪朋董浩马丽霞朱爱臣吴倩倩李俊起王传栋王勤
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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