Preparation method of novel drug vector-fusiform Au@mSiO2 compound

A compound and drug technology, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations of non-active ingredients, etc., can solve problems such as inability to directly realize loading and inconvenient loading, and achieve convenient drug loading and good sustained-release performance Effect

Inactive Publication Date: 2018-03-20
江苏顺德缘文化科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In addition, most of the current carriers need to be modified with amino groups, which cannot be directly loaded, and the loading is relatively inconvenient

Method used

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  • Preparation method of novel drug vector-fusiform Au@mSiO2 compound
  • Preparation method of novel drug vector-fusiform Au@mSiO2 compound
  • Preparation method of novel drug vector-fusiform Au@mSiO2 compound

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Embodiment 1

[0033] Such as Figure 1~4 As shown, the present invention is a novel drug carrier-fusiform Au@mSiO 2 The preparation method of compound comprises the following steps:

[0034] (1) Preparation of gold nanorod solution;

[0035] (2) Au@mSiO 2 preparation of

[0036] (3) Au@mSiO 2 Load MTX;

[0037] The first is the preparation of gold seed solution: completely dissolve 0.3553g CTAB in 9.75mL distilled water, add 0.25mL 0.01mol L -1 HAuCl 4 The solution was fully stirred under the condition of heating in a water bath at 28°C, and 0.60mL of 0.01mol·L -1 NaBH in cold water 4 The solution was stirred continuously for 2 minutes and then left to stand for 2-5 hours to obtain a gold seed solution;

[0038] Then the gold nanorod solution was prepared: 2.9156g CTAB was completely dissolved in 80.00mL of distilled water and stirred under the condition of heating in a water bath at 28°C, and 4.00mL of 0.01mol·L -1 HAuCl 4 Solution, 800μL 0.01mol·L -1 AgNO 3 Solution, 1600μL 1...

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Abstract

The invention relates to a preparation method of a novel drug vector-fusiform Au@mSiO2 compound, belonging to the field of drug vectors. A novel compound drug vector Au@mSiO2 is synthesized by takingfusiform Au as a core and mesoporous SiO2 as a shell. An anti-cancer drug methotrexate (MTX) is loaded by taking Au@mSiO2 as the vector, so that direct loading can be achieved, and therefore, the drugis more conveniently loaded. In addition, the whole releasing process of a product prepared by the method is relatively slow, and Au@mSiO2 has good slow release property.

Description

technical field [0001] The invention relates to a novel drug carrier-fusiform Au@mSiO 2 The preparation method of the complex belongs to the field of drug carriers. Background technique [0002] In recent years, due to Au and SiO 2 With the advantages of good biocompatibility, low toxicity, easy drug loading and modification, it has become a new type of drug carrier with great application prospects. [0003] In addition, most of the current carriers need to be modified with amino groups, which cannot be directly loaded, and the loading is relatively inconvenient. Contents of the invention [0004] According to the deficiencies in the prior art, the technical problem to be solved in the present invention is: to provide a new type of drug carrier-fusiform Au@mSiO 2 The preparation method of the composite, with fusiform Au as the core and mesoporous SiO 2 As the shell, a novel composite drug carrier Au@mSiO was synthesized 2 . And with Au@mSiO 2 As a carrier to load th...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K47/54A61K31/519A61P35/00
CPCA61K31/519
Inventor 宋福贵
Owner 江苏顺德缘文化科技股份有限公司
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