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Method for synthesizing medium-long-chain structure ester by enzymic method

An enzymatic synthesis, medium and long chain technology, applied in the field of oil and ester synthesis and modification, can solve the problems of high production of by-products, large amount of enzyme, and high acid value, so as to reduce the amount of enzyme, reduce the amount of production, and improve economic benefits. Effect

Inactive Publication Date: 2018-03-16
GUANGZHOU HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Invention patent application CN201010529356.6 and invention patent application CN201610411832.1 both reported the method of using immobilized lipase to synthesize medium and long chain structure esters. Too many by-products, such as high acid value, etc., are also common problems in the currently disclosed enzymatic synthesis technology.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take 6.4 kg of soybean oil as the raw material of long-chain triglycerides, 3.6 kg of caproic acid triglycerides as the raw material of medium-chain triglycerides, add the immobilized lipase Lipozyme TL which is 2% by weight of the total oils and esters, which is ground and passed through a 100-mesh sieve IM was used as a catalyst, vacuum stirred and heated to reflux in a 65°C water bath for 4 h, and the stirring rate was 100 r / min. After the reaction was completed, the immobilized lipase was removed by vacuum filtration with double-layer filter paper to obtain a medium-long chain structure ester sample, and the sample was determined The MLCT content is 76.31%, the acid value is 4.24 mg / g, and the diglyceride content is 7.10%.

Embodiment 2

[0032] Take 6.4 kg tea seed oil as the long-chain triglyceride raw material, 2.0 kg caprylic triglyceride as the medium-chain triglyceride raw material, add the immobilized lipase Lipozyme RL IM which is ground and passed through 80 mesh sieve with 2% of the total oil weight As a catalyst, it was heated and refluxed in a water bath at 45°C for 4 h under vacuum stirring at a stirring rate of 100 r / min. After the reaction was completed, the immobilized lipase was removed by vacuum filtration with double-layer filter paper to obtain a medium-long chain structure ester sample. The MLCT content is 65.33%, the acid value is 9.46mg / g, and the diglyceride content is 10.01%.

Embodiment 3

[0034] Take 6.4 kg of olive oil as the raw material of long-chain triglycerides, 3.6 kg of capric triglycerides as the raw material of medium-chain triglycerides, add the immobilized lipase Lipozyme 435 which is ground and passed through a 200-mesh sieve with 2% of the total oil weight as the Catalyst, vacuum stirring and heating under 80°C water bath for 1 h, the stirring rate is 30 r / min, after the reaction is completed, the immobilized lipase is removed by vacuum filtration with double-layer filter paper, and the ester sample with medium and long chain structure is obtained, and the MLCT in the sample is determined. The content is 74.88%, the acid value is 7.74 mg / g, and the diglyceride content is 8.40%.

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Abstract

The invention discloses a method for synthesizing medium-long-chain structure ester by an enzymic method. Crushed immobilized lipase is used as a catalyst; long-chain triglyceride and medium-chain triglyceride are fed according to a mass ratio of 6.4 to (2 to 10); the reaction temperature is 45 to 80 DEG C; the stirring reaction is performed for 1 to 10h in the vacuum state. When the method is used for preparing the medium-long-chain structure ester, the enzyme consumption can be reduced; the reaction time is shortened; the generation quantity of byproducts such as diglyceride is reduced; theproduct acid value is reduced; the high target product yield is maintained, so that the target product production cost is reduced; the economic benefits are improved.

Description

[0001] technical field [0002] The invention belongs to the technical field of synthesis and modification of oily esters, and in particular relates to a method for enzymatically synthesizing esters with medium and long chain structures. Background technique [0003] Studies have shown that the metabolic process of fatty acids in the human body is closely related to its type and the position of fatty acids on the glycerol skeleton. The reason is that in the process of human body's metabolism of triglycerides, lipase only hydrolyzes Sn-1 and 3 fatty acids. It is absorbed in the form of free fatty acid, while Sn-2 fatty acid is absorbed in the form of monoglyceride, and the type of Sn-2 fatty acid will not affect this process. In addition, free unsaturated fatty acids are easier to be absorbed by the body than free saturated fatty acids, and free saturated fatty acids are easy to react with calcium to form insoluble soap calcium and be excreted. Therefore, if the essenti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P7/64
CPCC12P7/6454
Inventor 唐顺之关伟键江程袁诚蔡鸿飞许文东牟肖男潘裕清吴伟锋王小妹杨阳李康强龙海林李海波
Owner GUANGZHOU HANFANG PHARMA
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