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A method for determining the fingerprint of Qibai Pingfei granules and its fingerprint

A fingerprint and particle technology, used in instruments, measuring devices, scientific instruments, etc., to achieve the effect of simple method, good reproducibility, accurate authenticity

Active Publication Date: 2019-11-12
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the fingerprint of the compound prescription

Method used

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  • A method for determining the fingerprint of Qibai Pingfei granules and its fingerprint
  • A method for determining the fingerprint of Qibai Pingfei granules and its fingerprint
  • A method for determining the fingerprint of Qibai Pingfei granules and its fingerprint

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Embodiment Construction

[0052] The embodiments of the present invention will be described in detail below in conjunction with examples. If specific conditions are not indicated in the examples, the procedures shall be carried out in accordance with conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used without the manufacturer's indication are all conventional products that are commercially available.

[0053] 1 Fingerprint and content determination

[0054] 1.1 Instruments and reagents

[0055] Ultimate 3000HPLC, DAD ultraviolet detector (Thermo Fisher Technology, USA); Mettler AE240 electronic analytical balance (Mettler, Switzerland); Mettler XP6 electronic analytical balance (Mettler, Switzerland); Centrifuge 5415D high-speed centrifuge ( Eeppendorf, Germany); Milli-Q Academic pure water machine (Millipore, USA); KQ-250DB ultrasonic cleaner (Kunshan Ultrasonic Instrument Co., Ltd.).

[0056] Schisandrin A reference substance (batch number: 110857-201513, ...

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Abstract

The invention discloses a method for determining the fingerprint of a Qibai Pingfei granule, and the fingerprint of the granule. The method comprises the following steps: respectively carrying out extraction on a Qibai Pingfei granule sample and schizandrin by using a methanol solution to obtain a sample solution and a reference substance solution, and carrying out high performance liquid chromatography on the sample solution and the reference substance solution by using the schizandrin, caffeic acid, ferulic acid, deoxyschizandrin, schisandrin B and schisantherin A as reference substances toobtain the fingerprint. The fingerprint of the Qibai Pingfei granule, established by using the method, can effectively characterize the quality of the Qibai Pingfei granule, and is in favor of comprehensively monitoring the quality of medicinal materials. The method has the advantages of simplicity, stability, high precision and good reappearance, and can be used to rapidly and accurately identifythe authenticity and the quality.

Description

Technical field [0001] The invention belongs to the technical field of quality identification of traditional Chinese medicines, and in particular relates to a method for determining the fingerprint spectrum of Qibaipingfei granules and a fingerprint spectrum of Qibaipingfei granules established by the method. Background technique [0002] The fingerprint of Chinese medicine refers to the chromatogram or spectrum that can indicate the chemical characteristics of certain Chinese medicinal materials or Chinese medicinal preparations after proper processing and using certain analytical methods. The fingerprint of traditional Chinese medicine is a comprehensive and quantifiable identification method. It is based on the systematic study of the chemical components of traditional Chinese medicine. It is mainly used to evaluate the authenticity, excellence and stability of the quality of Chinese herbal medicines and semi-finished products of Chinese medicine preparations. "Integrity" and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/88G01N30/06
CPCG01N30/06G01N30/88
Inventor 萧伟付娟张海弢李家春王伟胡军华黄文哲王振中
Owner JIANGSU KANION PHARMA CO LTD
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