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Novel favipiravir crystal form

A technology of favipiravir and crystal form, which is applied in the field of preparation of raw materials, can solve the problem of not providing solubility of favipiravir crystal form, etc., and achieve the effect of good solubility

Inactive Publication Date: 2018-03-06
WEIHAI GUANBIAO INFORMATION TECH
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Prior art does not provide favipiravir crystal form with higher solubility

Method used

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  • Novel favipiravir crystal form
  • Novel favipiravir crystal form

Examples

Experimental program
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Effect test

Embodiment 2、16

[0020] Example 2. Dissolve 16 g of Favipiravir powder in 100 ml of ethanol, filter, adjust the pH of the filtrate to 6.8 with 0.1 mol / l hydrochloric acid or 0.1 mol / l sodium hydroxide, and cool to -6°C under stirring. Crystals are precipitated, and 500ml of ethanol is added to the solution at a flow acceleration rate of 4.6ml / min. After the dropwise addition is completed, the pH of the solution is adjusted to 6.8 with 0.1mol / l hydrochloric acid or 0.1mol / l sodium hydroxide, and at this temperature, continue to stir 4 hours, crystal growth for 3 hours, filtered to obtain the crystal form of the present invention, its X-ray diffraction pattern is shown in the attached figure 1 , The purity determined by high performance liquid chromatography was 99.87%, and the yield was 91.98%.

[0021] Example 3. Dissolve 14 g of Favipiravir powder in 100 ml of isopropanol, filter, adjust the pH of the filtrate to 6.5 with 0.1 mol / l hydrochloric acid or 0.1 mol / l sodium hydroxide, and cool to ...

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Abstract

The invention relates to a new crystal form of favipiravir, which belongs to the technical field of preparation of raw materials. The technical solution of the present invention is: a new crystal form of favipiravir. In the powder X-ray diffraction of the crystal form, the 2θ° is 7.4, 8.5, 11.1, 15.4, 17.8, 18.5, 19.2, 21.0, 21.8, 22.6, There are strong absorption peaks near 23.5 and 26.4. The technical solution of the present invention provides a favipiravir crystal form with good solubility, which plays a positive role in the improvement of the favipiravir preparation.

Description

technical field [0001] The invention relates to a new crystal form of favipiravir, which belongs to the technical field of preparation of raw materials. Background technique [0002] Influenza (abbreviated as influenza) is an acute respiratory infection caused by influenza virus, and it is also a highly contagious and fast-spreading disease. It is mainly spread through droplets in the air, person-to-person contact or contact with contaminated items. Typical clinical symptoms are: sudden onset of high fever, general pain, significant fatigue and mild respiratory symptoms. Generally, autumn and winter are the high-incidence period, and the complications and death caused by it are very serious. The disease is caused by influenza virus, which can be divided into three types: A (A), B (B), and C (C). Type A virus often undergoes antigenic mutation, is highly contagious, spreads rapidly, and is prone to large-scale epidemics. [0003] Favipiravir (Favipiravir), the chemical nam...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D241/24
CPCC07D241/24C07B2200/13
Inventor 孙爱梅
Owner WEIHAI GUANBIAO INFORMATION TECH
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