Rana japonica oil coated drop pill preparation method

A technology of Rana oleifera oil and coating, which is applied in the directions of sugar-coated pills, medical preparations with inactive ingredients, and pill delivery, etc., to achieve the effects of fast onset, uniform dispersion and uniform release.

Inactive Publication Date: 2018-03-06
JILIN AGRI SCI & TECH COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research on the dosage forms of Rana oil products in the market has certain limitations, but they are mainly soft capsules, and there are some common dosage forms such as oral liquids, granules, soft capsules, and granules, and there are few other new preparations

Method used

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  • Rana japonica oil coated drop pill preparation method
  • Rana japonica oil coated drop pill preparation method
  • Rana japonica oil coated drop pill preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0016] single factor test

[0017] Drug-to-substrate ratio selection

[0018] Because the anti-aging effect of wood frog oil is mainly based on water-soluble protein, the water-soluble matrix PEG4000 and PEG6000 are selected. After the pre-example, it is better to mix PEG4000 and PEG6000 as the matrix. In this example, simethicone is used as the cooling medium. The results are shown in Table 1. (The evaluation index is: the appearance is uniform brownish yellow, round and no tailing, no adhesion, moderate hardness, and the surface is bright after drying, the total score is 25 points)

[0019] Table 1 Selection results of drug-matrix ratio

[0020]

[0021] From the results of the examples, it can be seen that the roundness is not good when the matrix content is small, and the tailing and adhesion are serious, and the glossiness is poor if the matrix content is too high, so the ratio of material to matrix is ​​about 1:2:2.

[0022] Choice of material temperature

[0023]...

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PUM

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Abstract

The invention discloses a rana japonica oil coated drop pill preparation method which comprises the following steps: weighing a proper amount of rana japonica oil, smashing by a smashing machine, adding molten matrix, evenly stirring, then keeping material temperature at 85 DEG C, pouring into a pill dropping machine, adjusting a dropping speed, controlling a dropping distance as 6cm and droppinginto 10 DEG C dimethyl silica-based silicone oil to be cooled for 15min; taking out condensed pills, removing a coolant on the surfaces of the drop pills and air drying to obtain pill cores; coating the obtained pill cores, wherein in a coating solution, a content of a film forming agent is 2%, a content of a plasticizer is 0.6%, and a ratio of alcohol to water is 30 to 70. The drop pill disclosedby the invention has the characteristics of quick effect and even dispersion, and an accumulative dissolution rate in vivo of the drop pill exceeds 90%; furthermore, the drop pill has the advantage of even release, and reference basis is provided for application researches of the rana japonica oil.

Description

technical field [0001] The invention relates to the field of medicament preparation, in particular to a preparation method of wood frog oil-coated dripping pills. Background technique [0002] Chinese forest frogs are commonly known as frogs and husky toads. They are mainly produced in Heilongjiang, Jilin, and Liaoning provinces, especially in Jilin province, and are mainly distributed in the Changbai Mountain area. Rana oil is the dry product of female Rana oviduct, which contains a variety of nutrients and health factors. The research on the dosage forms of Rana oil products in the market has certain limitations, but mainly soft capsules, some oral liquids, granules, soft capsules, granules and other common dosage forms, and other new preparations are less. Considering its market application expansion, it is necessary to carry out diversified development of Rana oil products. Dropping pills have the characteristics of fast onset of action and uniform dispersion, and the c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/65A61K9/36A61K47/10A61K47/38
CPCA61K9/2031A61K9/2866A61K9/2893A61K35/65
Inventor 陈冰王政业
Owner JILIN AGRI SCI & TECH COLLEGE
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