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Swimming exercise and low-fat diet coordinated intervention method for hypertensive rat in development stage

A low-fat diet and developmental technology, applied in the medical field, can solve problems such as negative effects on memory function and inaccurate fat content, and achieve the effects of improving damage, maintaining learning and memory, and hippocampal synaptic plasticity

Inactive Publication Date: 2018-03-06
TIANJIN MEDICAL UNIV
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Problems solved by technology

[0007] The invention overcomes the inaccurate fat content of the existing low-fat diet and its negative effect on the neurodevelopmental learning and memory function of the developing hypertensive rats

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  • Swimming exercise and low-fat diet coordinated intervention method for hypertensive rat in development stage
  • Swimming exercise and low-fat diet coordinated intervention method for hypertensive rat in development stage
  • Swimming exercise and low-fat diet coordinated intervention method for hypertensive rat in development stage

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Embodiment Construction

[0055] combined with figure 1 , 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 describe in detail the specific embodiments of the present invention.

[0056] 1. Experimental animals and grouping: 80 spontaneously hypertensive rats were selected, all of which were 3-week-old weaned male rats. SHR rats were randomly divided into four groups: control group, swimming exercise intervention group, low-fat diet intervention group, swimming and low-fat diet combined intervention group.

[0057] 2. Swimming and low-fat diet intervention methods

[0058] (1) Swimming is non-weight-bearing swimming, and 60min / d swimming intervention is implemented, 6 days a week.

[0059] (2) The normal feed was AIN-93G for developing rats. The soybean oil content of the low-fat diet was 1 / 2 of that of the normal diet.

[0060] (3) Swimming and low-fat diet intervention time is 6 weeks.

[0061] 3. Non-invasive blood pressure measurement of the tail artery of SHR rats in different intervention groups at the deve...

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Abstract

The invention relates to a swimming exercise and low-fat diet coordinated intervention method for a hypertensive rat in the development stage. By means of the method, the defects are overcome that thecontent of the fat in an existing low-fat diet is uncertain, and the low-fat diet has negative effects on the neural development learning and memorizing functions of the hypertensive rat in the development stage. In the method, the swimming exercise (60 minutes a day and six days a week) and low-fat diet (the energy supply of the fat is 10.7%) coordinated intervention is provided, the neural development of the hypertensive rat in the development stage is ensured, and meanwhile, the blood pressure decreasing effect is achieved. The blood pressure decreasing effect of the coordinated intervention method on the hypertensive rat in the development stage is better than that of a separate swimming exercise or low-fat diet method on the hypertensive rat in the development stage, meanwhile, the damage of the low-fat diet to the spatial learning and memorizing ability and the hippocampal neural synapse plasticity of the rat is reduced, and the neural development learning and memorizing functions of the hypertensive rat in the development stage are promoted.

Description

technical field [0001] The invention relates to a coordinated intervention method of swimming exercise and low-fat diet for developing hypertensive rats, belonging to the medical field. Background technique [0002] Epidemiological surveys have confirmed that adult hypertension mostly originated in childhood. Hypertension in children will lead to early and younger cardiovascular diseases, together with other risk factors, increase the mortality and disease burden of cardiovascular diseases, and become one of the chronic cardiovascular diseases that seriously endanger children's health. Antihypertensive drugs are currently known methods of controlling blood pressure. However, each antihypertensive drug has toxic side effects, especially in developing children. Therefore, the application of non-pharmaceutical prescriptions to control blood pressure is an important intervention method for the prevention and treatment of hypertension in children. Reducing fat intake is a safe...

Claims

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Application Information

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IPC IPC(8): A01K67/02
CPCA01K67/02A01K2207/25
Inventor 臧小英赵岳程梅
Owner TIANJIN MEDICAL UNIV
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