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Medicine for treating metrorrhagia caused after medical abortion

A treatment drug and technology for uterine bleeding, applied in the field of medicine, can solve problems such as increased bleeding volume and prolonged bleeding time

Inactive Publication Date: 2018-02-27
王玉美
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, prolongation of bleeding time and increased bleeding volume after medical abortion are the main complications, which have become clinical problems to be solved.

Method used

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  • Medicine for treating metrorrhagia caused after medical abortion
  • Medicine for treating metrorrhagia caused after medical abortion
  • Medicine for treating metrorrhagia caused after medical abortion

Examples

Experimental program
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Effect test

experiment example

[0053] The structural formula of the pharmaceutical compound of the present invention is:

[0054]

[0055] 90 healthy non-pregnant SD female rats were caged with male rats at a ratio of 2:1, and vaginal smear examination was carried out in the morning of the next day, and it was the first day of pregnancy to find that there were sperm. Select 60 successfully mated female mice, and randomly divide them into 6 groups according to body weight, 10 in each group, which are normal pregnancy group, model control group, and positive control group (Gongxuening Capsules, purchased from Yunnan Baiyao Pharmaceutical Co., Ltd. ) and the low, middle and high dose groups of the medicine of the present invention. Except for the normal pregnancy group, the other groups were administered mifepristone 12.50 mg / kg (9:00) and misoprostol 0.12 mg / kg (17:00) by intragastric administration on the 7th day of pregnancy. Put in a quantitative cotton ball (the weight of the cotton ball is 90 mg). T...

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Abstract

The invention relates to a medicine for treating metrorrhagia caused after medical abortion. The medicine is prepared from an effective dose of compound with a structural formula described in the description, pharmacologically acceptable salts, esters or prodrugs of the compound, and a pharmacologically acceptable carrier, wherein R1 is hydrogen, C1-6 alkyl, single-halogenated or polyhalogenated C1-6 alkyl, C1-6 alkyl substituted with one or two hydroxy groups, or C1-6 alkyl substituted with one substituent group, and the substituent group is selected from a group consisting of the following items: cyano group and C1-4 alkoxy; R2 is hydrogen, C1-6 alkyl, single-halogenated or polyhalogenated C1-6 alkyl, C1-6 alkyl substituted with one or two hydroxyl groups, or C1-6 alkyl substituted withone substituent group, and the substituent group is selected from a group consisting of the following items: cyano group and C1-4 alkoxy; R3 is hydrogen, C1-4 alkoxy, hydroxyl, cyano group, C1-4 alkylor halogen; R4 is hydrogen, C1-4 alkoxy, hydroxyl, cyano group, C1-4 alkyl or halogen. The medicine has a hemostasis effect on the metrorrhagia caused after medical abortion.

Description

technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to a medicine for treating uterine bleeding after drug abortion. Background technique [0002] Medical abortion refers to the method of terminating pregnancy by taking medicine instead of surgery. Because of its convenience, less pain and remarkable curative effect, it is welcomed by women of childbearing age and widely used in clinic. However, prolongation of bleeding time and increased bleeding volume after medical abortion are the main complications, which have become clinical problems to be solved. Contents of the invention [0003] The object of the present invention is to provide a medicine for treating uterine bleeding after medical abortion. [0004] In order to realize the object of the present invention, the present invention provides a kind of medicine for the treatment of uterine hemorrhage after medical abortion, and described medicine comprises: effect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4439A61P7/04A61P15/00
CPCA61K31/4439
Inventor 王玉美
Owner 王玉美
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