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A medicine for treating uterine bleeding after medical abortion

A technology for the treatment of drugs and uterine bleeding, applied in the field of medicine, can solve problems such as increased bleeding volume and prolonged bleeding time

Inactive Publication Date: 2017-09-22
鄄城县人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, prolongation of bleeding time and increased bleeding volume after medical abortion are the main complications, which have become clinical problems to be solved.

Method used

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  • A medicine for treating uterine bleeding after medical abortion
  • A medicine for treating uterine bleeding after medical abortion
  • A medicine for treating uterine bleeding after medical abortion

Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0053] The structural formula of the pharmaceutical compound of the present invention is:

[0054]

[0055] 90 healthy non-pregnant SD female rats and male rats were caged at a ratio of 2:1, and vaginal smears were performed the next morning. The first day of pregnancy was found to have sperm. A total of 60 female mice successfully mated were selected and randomly divided into 6 groups according to their body weights, each with 10 mice, namely the normal pregnancy group, the model control group, and the positive control group (Gongxuening Capsules, purchased from Yunnan Baiyao Pharmaceutical Co., Ltd. ) And the low, medium and high dose groups of the drug of the present invention. Except for the normal pregnancy group, all the other groups were given mifepristone 12.50mg / kg (9:00) and misoprostol 0.12mg / kg (17:00) respectively on the 7th day of pregnancy. Into a quantitative cotton ball (cotton ball weight 90mg). The next day, the cotton ball was taken out at 9:00 and 17:00, wr...

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PUM

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Abstract

The invention relates to a medicine for treating uterine hemorrhage after drug abortion. The medicine includes, in effective dose, a compound, which has the structural formula represented in the specification, and pharmaceutically acceptable salts, esters or prodrugs of the compound, and a pharmaceutically acceptable carrier, wherein R1 is hydrogen, a C1-C6 alkyl group, a mono- or poly-halogenated C1-C6 alkyl group, a C1-C6 alkyl group substituted by one or two hydroxyl groups, or a C1-C6 alkyl group substituted by one substitutive group selected from a cyano group and a C1-C4 alkoxyl group; R2 is hydrogen, a C1-C6 alkyl group, a mono- or poly-halogenated C1-C6 alkyl group, a C1-C6 alkyl group substituted by one or two hydroxyl groups, or a C1-C6 alkyl group substituted by one substitutive group selected from a cyano group and a C1-C4 alkoxyl group; R3 is hydrogen, a C1-C4 alkoxyl group, a hydroxyl group, a cyano group, a C1-C4 alkyl group or a halogen; and R4 is hydrogen, a C1-C4 alkoxyl group, a hydroxyl group, a cyano group, a C1-C4 alkyl group or a halogen. The medicine has a hemostatic effect on the uterine hemorrhage after drug abortion.

Description

Technical field [0001] The invention relates to the field of medicine. Specifically, the invention relates to a medicine for treating uterine bleeding after medical abortion. Background technique [0002] Medical abortion refers to the method of terminating pregnancy by taking drugs instead of surgery. Because of its convenience, less pain, and remarkable curative effect, it is welcomed by women of childbearing age and is widely used in clinical practice. However, prolonged bleeding time and increased bleeding after medical abortion are the main complications, which have become problems to be solved in clinical letters. Summary of the invention [0003] The purpose of the present invention is to provide a medicine for treating uterine bleeding after medical abortion. [0004] In order to achieve the purpose of the present invention, the present invention provides a medicament for treating uterine bleeding after medical abortion, the medicament comprising: an effective amount of a c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4439A61P7/04A61P15/00
CPCA61K31/4439
Inventor 王玉美
Owner 鄄城县人民医院
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