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Medicine for treating uterine hemorrhage after drug abortion

A technology of uterine bleeding and treatment drugs, applied in the field of medicine, can solve problems such as increased bleeding volume and prolonged bleeding time

Inactive Publication Date: 2017-04-26
鄄城县人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, prolongation of bleeding time and increased bleeding volume after medical abortion are the main complications, which have become clinical problems to be solved.

Method used

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  • Medicine for treating uterine hemorrhage after drug abortion
  • Medicine for treating uterine hemorrhage after drug abortion
  • Medicine for treating uterine hemorrhage after drug abortion

Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0053] The structural formula of the pharmaceutical compound of the present invention is:

[0054]

[0055] Ninety healthy non-pregnant SD female rats were caged with male rats at a ratio of 2:1, and vaginal smear examination was performed the next morning, and the first day of pregnancy was found to have sperm. Select 60 successfully mated female mice, and randomly divide them into 6 groups according to body weight, 10 in each group, which are normal pregnancy group, model control group, and positive control group (Gongxuening Capsules, purchased from Yunnan Baiyao Pharmaceutical Co., Ltd. ) and the low, middle and high dose groups of the medicine of the present invention. Except for the normal pregnancy group, the other groups were administered mifepristone 12.50 mg / kg (9:00) and misoprostol 0.12 mg / kg (17:00) by intragastric administration on the 7th day of pregnancy. Enter a quantitative cotton ball (cotton ball weight 90mg). The next day, the cotton balls were taken ...

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PUM

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Abstract

The invention relates to a medicine for treating uterine hemorrhage after drug abortion. The medicine includes, in effective dose, a compound, which has the structural formula represented in the specification, and pharmaceutically acceptable salts, esters or prodrugs of the compound, and a pharmaceutically acceptable carrier, wherein R1 is hydrogen, a C1-C6 alkyl group, a mono- or poly-halogenated C1-C6 alkyl group, a C1-C6 alkyl group substituted by one or two hydroxyl groups, or a C1-C6 alkyl group substituted by one substitutive group selected from a cyano group and a C1-C4 alkoxyl group; R2 is hydrogen, a C1-C6 alkyl group, a mono- or poly-halogenated C1-C6 alkyl group, a C1-C6 alkyl group substituted by one or two hydroxyl groups, or a C1-C6 alkyl group substituted by one substitutive group selected from a cyano group and a C1-C4 alkoxyl group; R3 is hydrogen, a C1-C4 alkoxyl group, a hydroxyl group, a cyano group, a C1-C4 alkyl group or a halogen; and R4 is hydrogen, a C1-C4 alkoxyl group, a hydroxyl group, a cyano group, a C1-C4 alkyl group or a halogen. The medicine has a hemostatic effect on the uterine hemorrhage after drug abortion.

Description

technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to a medicine for treating uterine bleeding after medical abortion. Background technique [0002] Medical abortion refers to the method of terminating pregnancy by taking drugs instead of surgery. Because of its convenience, less pain, and remarkable curative effect, it is welcomed by women of childbearing age and widely used clinically. However, prolongation of bleeding time and increased bleeding volume after medical abortion are the main complications, which have become clinical problems to be solved. Contents of the invention [0003] The object of the present invention is to provide a medicine for treating uterine bleeding after medical abortion. [0004] In order to realize the object of the present invention, the present invention provides a kind of medicine for the treatment of uterine hemorrhage after medical abortion, and described medicine comprises: effe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4439A61P7/04A61P15/00
CPCA61K31/4439
Inventor 孟洁
Owner 鄄城县人民医院
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