Chip structure

Abstract

The invention discloses a chip structure. The chip structure includes a chip main body, a channel in the chip main body, and a reference unit and a cell unit which are arranged in the channel, the chip main body is provided with a projection which is positioned between the reference unit and the cell unit in the channel, two sides of the protrusion and two sidewalls of the channel are respectivelyconnected or form an integral body, the upper surface of the protrusion is higher than the respective bottom surface of the reference unit and the cell unit in the channel, the upper surface of the protrusion is spaced from the top surface of the channel to make the reference unit and the cell unit communicate with each other, a sample inlet leading to the external of the chip main body is arranged at one end of the channel, and a sample outlet leading to the external of the chip main body is arranged at the other end of the channel, wherein the cell unit is the chip module, used for cell culture and signal detection, of the channel. The chip structure is simple to operate, can avoid bubbles, and can realize simultaneous detection of multiple samples.

Description

technical field [0001] The present invention relates to the technical field of chips, and in particular, to a chip structure. Background technique [0002] Pharmacokinetics studies the changes and laws of drugs under the influence of the body, including drugs, hormones, nutrients and toxins. Pharmacokinetics studies the in vivo process of drugs (including absorption, distribution, metabolism and excretion), and uses mathematical principles and methods to explain the dynamic laws of drugs in the body. [0003] Pharmacokinetic analysis often relies on mass spectrometry techniques, using liquid chromatography-mass spectrometry to simultaneously separate and analyze metabolites. Compared with these large instruments, microfluidic chip and biochip technology has the advantages of small size and high degree of integration. Microfluidic chips can be detected by a variety of detection methods, such as optical (refractive index, fluorescence, bioluminescence, chemiluminescence, Ram...

AI Technical Summary

Problems solved by technology

However, the split-type flow channel design requires external connection pipes, which increases the difficulty of operation, and it is easy to bring air into the pipe connection and conversion operations to generate air bubbles, and the external pipes are huge in volume, and the signal generated by the radioactive solution in them will be affected. A certain amount of noise interference to the detection

In this case, the detection of more samples in the same chip has brought limitations, especially in the research of the organ-on-a-chip laboratory with potential wider applications, bringing certain technical difficulties and challenges

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