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MicroRNA and application thereof in preparation of antitumor drugs

An anti-tumor drug, drug technology, applied in anti-tumor drugs, DNA/RNA fragments, drug combinations, etc., can solve problems such as cytokine storm

Active Publication Date: 2018-02-16
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although preliminary clinical trial results showed that MRX34 had acceptable efficacy and safety, the clinical trial was discontinued due to cytokine storm in 5 patients

Method used

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  • MicroRNA and application thereof in preparation of antitumor drugs
  • MicroRNA and application thereof in preparation of antitumor drugs
  • MicroRNA and application thereof in preparation of antitumor drugs

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Embodiment Construction

[0031] The present invention provides microRNA and its application in the preparation of antitumor drugs. Those skilled in the art can refer to the content of this article and appropriately improve the process parameters to realize it. In particular, it should be pointed out that all similar replacements and modifications are obvious to those skilled in the art, and they are all considered to be included in the present invention. The method and application of the present invention have been described through preferred embodiments, and relevant personnel can obviously make changes or appropriate changes and combinations to the method and application herein without departing from the content, spirit and scope of the present invention to realize and apply the present invention Invent technology.

[0032] The terms mentioned in the description of the present invention are defined as follows:

[0033] The RNA molecule provided by the present invention is a microRNA (microRNA, or m...

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Abstract

The invention relates to the technical field of bio-pharmacy, in particular to microRNA and an application thereof in preparation of antitumor drugs. Any one basic group in the 10th-22nd positions of5' end of a miR-34a sequence of the RNA molecule mutates into n which is A, C, G or U; the RNA molecule and complementary chains thereof can inhibit protein levels of PD-L1, B7-H3, B7-H4 and the likein tumor cells and inhibit growth and / or proliferation of the tumor cells to play an antitumor role. Besides, researches show that the microRNA has no significant effects on secretion of cell factorsin serum in the antitumor process.

Description

technical field [0001] The invention relates to the technical field of biopharmaceuticals, in particular to microRNA and its application in the preparation of antitumor drugs. Background technique [0002] The morbidity and mortality of malignant tumors in our country are increasing year by year, which has attracted more and more attention from the medical field, and has also become a major topic of basic research and clinical research. Although some progress has been made in tumor treatment, there is still a certain distance from the fundamental improvement of survival period and the requirements for quality of life. More efforts are still needed to explore safer and more effective adjuvant therapy. At present, tumor immunotherapy has become an effective therapy after surgery, chemotherapy and radiotherapy, and is widely used in clinic, especially the blocking therapy based on immune card control points. Effective anti-tumor immunotherapy depends on the efficient activatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/113C12N15/11A61K31/7115A61P35/00A61P35/02
CPCA61K31/7115C12N15/113C12N2310/141
Inventor 汪维鹏孟凡义邱雅静孔洁红陈喜华
Owner SUZHOU UNIV
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