Application of compound in improvement of cognition and memory ability and reduction of senile plaques

A technology of memory ability and compound, applied in the direction of drug combination, active ingredients of ketones, nervous system diseases, etc., can solve problems such as no reports, and achieve the effect of improving learning and memory ability

Inactive Publication Date: 2018-02-02
NORTHEAST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Until 2017, there were about 65 literature searches for reports on the function of Hispolon monomers, most of which focused on the exploration of the signaling pathway of Hispolon as a mushroom extract in potential anticancer drugs, Hispolon and Alzheimer's disease No relevant research has been reported

Method used

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  • Application of compound in improvement of cognition and memory ability and reduction of senile plaques
  • Application of compound in improvement of cognition and memory ability and reduction of senile plaques
  • Application of compound in improvement of cognition and memory ability and reduction of senile plaques

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Behavioral experiment of embodiment 1 Hispolon on APP / PS1 transgenic mice

[0026] The wild-type (WT) and APP / PS1 double transgenic mice used in the experiment of the present invention were purchased from the Model Animal Research Institute of Nanjing University, and the mouse genes were identified strictly according to the PCR method provided by the supplier. The 8-month-old APP / PS1 transgenic mice were set as the Hispolon-administered group, the Aricept-administered group, and the normal saline control group 1, and another group of WT wild-type mice was set as the control group 2. moon.

[0027] In the Y maze experiment, three black bar-shaped long arms with the same appearance are set up in a Y-shaped combination. The three long arms are marked as A, B, and C. The mice are put in from the A arm, and if they turn back from the other long arm during free movement It is recorded as an error, such as ABA, BCB, etc. When an error occurs, it will be recalculated with this...

Embodiment 2

[0031] Pathological experiment of the effect of embodiment 2 Hispolon on APP / PS1 transgenic mouse brain tissue

[0032] 10-month-old AD mice were anesthetized with 0.4% pentobarbital sodium, blood was collected by perfusing the atrium, the whole body was fixed by perfusion of the heart with 4% paraformaldehyde, the brain tissue was taken and weighed, and half of the brain was placed in 4% paraformaldehyde solution It was used for histopathology, and the other half was stored in a cryopreservation tube at -80°C for biochemical analysis. The 4% paraformaldehyde-fixed brain tissue was embedded in wax and sectioned, and the deposition plaques in the cerebral cortex and hippocampus were stained by Thioflavin S and Congo red. Pathological images were acquired by digital microscope and fluorescence microscope and analyzed quantitatively.

[0033] The results of Thioflavin S staining and Congo red staining of brain tissue were as follows: Figure 4 , Figure 5 As shown, whether in ...

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Abstract

The invention discloses an application of Hispolon in the improvement of the cognition and memory ability and the reduction of senile plaques. Alzheimer's disease (AD) is a neurodegenerative disease with nerve cell fiber entanglement, amyloid beta-protein (Abeta) plaque deposition and cognition function decline as pathologic characteristics, wherein Abeta extracellular toxic accumulation is considered as one of main attack links of the AD. It is found that the Hispolon can improve the spatial memory learning ability of AD mice and obviously clear amyloid plaques in APP / PS1 double transgenic ADmodel mice brain tissues, which shows that the Hispolon can be applied to the treatment of the AD and the development of related drugs.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the application of Hispolon in the preparation of medicines for treating Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD), also known as Alzheimer's disease, is clinically manifested as psychomotor abnormalities, language disorders, cognitive and memory impairments, and is a common progressive neurological decline in the elderly. According to the World Alzheimer's Report 2009, the number of people living with the disease will soar to 150 million by 2050 [1] . [0003] The most widely accepted theory about the pathogenesis of AD is the Aβ theory marked by the oligomerization of β-amyloid protein and the formation of fibrous precipitates. [2] . Under normal physiological conditions, the generation and degradation of Aβ from the hydrolysis of β-amyloid precursor protein (APP) by β- and γ-cleaving enzymes are in balance. Under pathological...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61P25/28
CPCA61K31/12
Inventor 李晓萌王立春李晓春汪小莞李佳乐刘孜育魏溦李江
Owner NORTHEAST NORMAL UNIVERSITY
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