A high skin cell penetration α-arbutin composition and its preparation method and application

A technology of skin cells and arbutin, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve difficult melanocyte whitening effects, poor skin penetration, effective use of limited skin retention, etc. , to achieve the effects of good skin permeability, strong intracellular penetration, excellent skin permeability and retention

Active Publication Date: 2020-12-29
广东乐尔康生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, due to the strong hydrophilicity of α-arbutin, the skin penetration is poor, and it is difficult to enter the melanocytes through the skin barrier to exert the whitening effect
Therefore, the low skin retention of α-arbutin limits its effective use in cosmetics

Method used

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  • A high skin cell penetration α-arbutin composition and its preparation method and application
  • A high skin cell penetration α-arbutin composition and its preparation method and application
  • A high skin cell penetration α-arbutin composition and its preparation method and application

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preparation example Construction

[0077] The present invention also provides a preparation method of the α-arbutin composition with high skin cell penetration, comprising the following steps:

[0078] mixing α-arbutin, quaternized soybean protein, stabilizer and water to obtain an aqueous phase;

[0079] mixing lecithin, polyols and co-emulsifiers to obtain an oil phase;

[0080] mixing the water phase with the oil phase to obtain a mixed solution;

[0081] The mixed solution is homogenized to obtain the α-arbutin composition with high skin cell penetration.

[0082] In the invention, alpha-arbutin, quaternized soybean protein, stabilizer and water are mixed to obtain the water phase. In the present invention, the mixing temperature is preferably 50-70°C, more preferably 55-70°C, most preferably 55-65°C. In the present invention, the mixing time is not particularly limited, as long as each raw material can be mixed uniformly. The method and rate of heating to the mixing temperature are not specifically lim...

Embodiment 1

[0097] Add 1% α-arbutin, 0.4% lauryl dimethyl ammonium hydroxypropyl hydrolyzed soybean protein, 1% xanthan gum, and 0.5% carbomer to 43.1% water, stir and dissolve in a water bath at 50°C , to obtain the aqueous phase, for subsequent use;

[0098] 1% hydrogenated soybean lecithin, 10% 1,2 propylene glycol, 20% glycerin, 20% 1,3-butanediol, 2% diethylene glycol monoethyl ether, 0.5% phenoxyethanol, 0.5% ethyl Hexylglycerin was stirred and dissolved in a water bath at 50°C to obtain an oil phase, which was set aside;

[0099] Mix the water phase and the oil phase, and keep stirring for 20 minutes in a water bath at 50°C to obtain a mixed solution of α-arbutin with high skin cell penetration;

[0100] The α-arbutin mixed solution with high skin cell penetration was homogenized for 4 minutes at a pressure of 500 bar and a temperature of 60° C., and circulated 6 times to obtain an α-arbutin composition with high skin cell penetration. The particle diameter of the α-arbutin compo...

Embodiment 2

[0102] Add 2% α-arbutin, 0.5% hydroxypropyltrimethylammonium chloride hydrolyzed soybean protein, and 0.5% gelatin to 67% water, stir and dissolve in a water bath at 55°C to obtain a water phase, and set aside;

[0103] 1% soybean lecithin, 1% hydrogenated soybean lecithin, 5% dipropylene glycol, 5% 1,2-hexanediol, 10% 1,3-butanediol, 1% caprylyl glycol, 2% butanol Ether-9, 1% poloxamer, and 4% potassium sorbate were stirred and dissolved in a water bath at 55°C to obtain an oil phase for later use;

[0104] Mix the water phase and the oil phase, and keep stirring for 25 minutes in a water bath at 55°C to obtain a mixed solution of α-arbutin with high skin cell penetration;

[0105] The α-arbutin mixed solution with high skin cell penetration was homogenized for 6 minutes at a pressure of 800 bar and a temperature of 70° C., and circulated 5 times to obtain an α-arbutin composition with high skin cell penetration. The α-arbutin composition with high skin cell penetration has ...

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Abstract

The invention provides a high-skin cell permeation alpha-arbutin composition as well as a preparation method and application thereof. The alpha-arbutin composition is prepared from the following components in percentage by mass: 1.0-15.0 percent of alpha-arbutin, 1.0-15.0 percent of lecithin, 0.4-6.0 percent of quaternary ammonium soybean protein, 15.0-50.0 percent of polyols, 2.0-10.0 percent ofa co-emulsifier, 0.1-1.5 percent of a stabilizer and the balance of water. The high-skin cell permeation alpha-arbutin composition provided by the invention is good in skin permeability, high in skindeposit amount, good in stability and large in drug loading amount, can efficiently promote the alpha-arbutin to permeate a skin barrier to reach a skincare target site and has remarkable whitening and spot removing effects. Meanwhile, the preparation method is simple, is liable to control, is green and environmentally friendly and is suitable for industrial production.

Description

technical field [0001] The invention relates to an α-arbutin composition, in particular to an α-arbutin composition with high skin cell penetration and its preparation method and application. Background technique [0002] α-arbutin is an epimer of β-arbutin, and its chemical name is 4-hydroxyphenyl-α-D-glucopyranoside. There are two structural functional groups in the molecular structure of α-arbutin: glucose residue and phenolic hydroxyl group. Glucose residues are hydrophilic, and phenolic hydroxyl groups have an inhibitory effect on melanin synthase. Therefore, α-arbutin can moisturize and whiten to a certain extent, and can be added to cosmetics as a whitening agent for whitening and freckle removal. effect. [0003] Studies have shown that α-arbutin can effectively inhibit the activity of tyrosinase in the skin without affecting the growth of skin cells, block the formation of melanin, and accelerate the decomposition of melanin by combining itself with tyrosinase An...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/60A61K8/64A61K8/34A61K8/55A61Q19/02
Inventor 刘卫吴培诚许琦周银泉
Owner 广东乐尔康生物科技股份有限公司
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