A compound traditional Chinese medicine transdermal spray for preventing and treating scabies in animals and its preparation method

A technology of compound Chinese medicine and scabies, which is applied in the direction of aerosol delivery, medical raw materials derived from arthropods, medical preparations with non-effective ingredients, etc. Inconvenience and other problems, to achieve the effect of strong stimulation of the animal body, promote the growth of new skin, and promote transdermal penetration

Active Publication Date: 2020-09-11
SHANXI AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The water decoction lotion is used in a large amount, and the skin penetration is poor. It is difficult for the active ingredients of the drug to penetrate the epidermis and penetrate deep into the epidermis of the skin to kill scabies mites in the skin tunnel; although the acaricide ointment has good skin penetration, it needs to be applied on the affected area , inconvenient to use, especially when treating large numbers of animals with scabies, it is almost impossible
[0013] A variety of traditional Chinese medicines have a killing effect on animal mites. In practice, they are often crushed or decocted for smearing, which has the problems of large dosage and inconvenient use.
However, the extraction techniques are different, and the active ingredients of each herb are also different, which has a great impact on the acaricidal effect. Therefore, it is considered that the use of a reasonable extraction method to retain the acaricidal components is the basis for the development of compound acaricidal preparations; In the treatment of animal scabies, there are problems of high dosage and poor acaricidal effect, while the existing prescriptions focus on acaricidal, and do not have the effects of sterilization, antipruritic and skin repair

Method used

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  • A compound traditional Chinese medicine transdermal spray for preventing and treating scabies in animals and its preparation method
  • A compound traditional Chinese medicine transdermal spray for preventing and treating scabies in animals and its preparation method
  • A compound traditional Chinese medicine transdermal spray for preventing and treating scabies in animals and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: A compound traditional Chinese medicine transdermal spray for preventing and treating scabies in animals, which is prepared by mixing the following components in parts by weight: 2 parts of Sophora flavescens alcohol extract, 4 parts of Radix radicis alcohol extract, Zanthoxylum bungeanum alcohol extract 3 parts, 1 part of chamaejasma ethanol extract, 4 parts of mixed water extract of neem, Kochia chinensis, five times, gardenia, 1 part of water-soluble vitamin, 4 parts of glycerin, 4 parts of Tween 80, 2 parts of borneol, 2 parts of azone, 4 parts of propylene glycol, 35 parts of 90% ethanol, 20 parts of distilled water; The ratio is 2:4:8:1 and the water extract obtained after water extraction is carried out.

[0039] The water-soluble vitamin used is: National Pharmaceutical Standard H32023002, produced by Huarui Pharmaceutical Co., Ltd. Each bottle contains: Thiamine nitrate 3.1mg, riboflavin sodium phosphate 4.9mg, nicotinamide 40mg, pyridoxine hydrochl...

Embodiment 2

[0043] Example 2: A compound traditional Chinese medicine transdermal spray for preventing and treating scabies in animals, which is prepared by mixing the following components in parts by weight: 1 part of Sophora flavescens alcoholic extract, 2 parts of Radix radicis alcoholic extract, Zanthoxylum bungeanum alcoholic extract 2 parts, 1 part of chamaejasma ethanol extract, 1 part of mixed water extract of neem, Kochia chinensis, five times, gardenia, 1 part of water-soluble vitamin, 4 parts of glycerin, 4 parts of Tween 80, 2 parts of borneol, 2 parts of azone, 4 parts of propylene glycol, 35 parts of 90% ethanol, 20 parts of distilled water; The ratio is 2:4:8:1 and the water extract obtained after water extraction is carried out. Its preparation method is the same as the preparation method described in Example 1.

Embodiment 3

[0044] Example 3: A compound traditional Chinese medicine transdermal spray for preventing and treating scabies in animals, which is prepared by mixing the following components in parts by weight: 3 parts of Sophora flavescens alcohol extract, 4 parts of Radix radicis alcohol extract, Zanthoxylum bungeanum alcohol extract 3 parts, 2 parts of chamaejasma ethanol extract, 1 part of mixed aqueous extract of neem, Kochia chinensis, five times, gardenia, 1 part of water-soluble vitamin, 4 parts of glycerin, 2 parts of Tween 80, 2 parts of borneol, 2 parts of azone, 4 parts of propylene glycol, 35 parts of 90% ethanol, 20 parts of distilled water; The ratio is 2:4:8:1 and the water extract obtained after water extraction is carried out. Its preparation method is the same as the preparation method described in Example 1.

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Abstract

The invention belongs to the technical field of animal traditional Chinese medicines and provides a compound traditional Chinese medicine transdermal spray for preventing and treating animal sarcopticacariasis and a preparation method of the transdermal spray aiming at solving the problems existing in the conventional chemical drugs and traditional Chinese medicine preparations for treating the animal sarcoptic acariasis. The transdermal spray is prepared by the following steps: mixing radix sophorae flavescentis, radix stemonae, Sichuan pepper, ethanol extract of radix euphorbiae lantu, melia azedarach, fructus kochiae, gallnut and jasmine mixed aqueous extract according to a certain ratio, adding water-soluble vitamins, glycerin, Tween 80, borneol, azone and propylene glycol according to a certain ratio for mixing, thereby obtaining the product. The transdermal spray is convenient to use, is capable of effectively transmitting through an epidermal layer of animal skin to kill sarcoptic mites in skin tunnels, and achieves the effects of clearing away heat and drying dampness, killing bacteria and diminishing inflammation, rapidly relieving itching, astringing to resist seepage, diminishing inflammation and relieving pain, controlling infection and promoting growth of new skin. The transdermal spray has the characteristics of broad spectrum, high efficiency, low toxicity, no residue, environmental friendliness, economy and convenience, is capable of effectively preventing and treating animal sarcoptic acariasis and can provide an effective drug and technical means for controlling the increasingly serious animal surface parasitic diseases at present.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine for animals, and in particular relates to a compound traditional Chinese medicine transdermal spray for preventing and treating scabies in animals and a preparation method thereof. Background technique [0002] Scabies, also known as scabies, scabies, leprosy, etc., is an intractable, chronic, contact, and highly contagious ectoparasitic disease caused by mites of the family Sarcaceae or Scabies. It is the ectoparasitic disease that causes the greatest loss to livestock and fur animals. The disease is characterized by eczematous dermatitis, hair loss, severe itching, crusting, depilation, skin thickening, dry cracking, formation of fish scales, local abrasions and bleeding, and emaciation of the affected animal body. , seriously affect animal development, production performance and fur quality, and even cause death. It has become the most harmful ectoparasitic disease in larg...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/904A61K9/12A61K47/10A61K47/22A61K47/26A61P33/14A61P17/00A61K35/64
Inventor 古少鹏李宏全郑明学贺俊平张建新
Owner SHANXI AGRI UNIV
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