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Pulse drug delivery formulation of antibiotic microspheres against drug-resistant bacteria

A technology of antibiotics and drug-resistant bacteria, applied in the field of medicine, can solve problems such as poor patient compliance and side effects, and failure to realize simultaneous transmission of pulse drug delivery systems, etc.

Active Publication Date: 2020-08-14
BEIJING YUEKANGKECHUANG PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Neither the above-mentioned nor the prior art realizes the pulsatile drug delivery system that simultaneously transmits a single drug or a drug combination, which makes the patient's treatment compliance poor and has relatively large side effects

Method used

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  • Pulse drug delivery formulation of antibiotic microspheres against drug-resistant bacteria
  • Pulse drug delivery formulation of antibiotic microspheres against drug-resistant bacteria
  • Pulse drug delivery formulation of antibiotic microspheres against drug-resistant bacteria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Embodiment 1 Pulse-type administration preparation of tipipenem microspheres

[0063] prescription:

[0064] Immediate Release Portion Prescription:

[0065] Tipipenem 10%

[0066] Microcrystalline Cellulose 90%

[0067] Hydroxypropyl Cellulose 5%

[0068] Delayed 4 hour partial prescription:

[0069]

[0070] Delayed 8 hours partial prescription:

[0071]

[0072] Preparation method:

[0073] (1) Preparation of immediate release part:

[0074] (1.1) Pulverizing tipipenem ester and microcrystalline cellulose, the powder is sieved respectively through a 100-mesh sieve;

[0075] (1.2) Take the pulverized tipipenem ester and microcrystalline cellulose and add them to the wet granulator, the stirring speed is 800r / min, and the stirring time is 3min, so that the tipipenem ester and microcrystalline cellulose are mixed evenly, add The hydroxypropyl cellulose aqueous solution with a mass concentration of 5% is uniformly mixed in a wet granulator, the stirring spe...

Embodiment 2

[0089] Embodiment 2 The pulse type administration preparation of tipipenem microspheres

[0090] prescription:

[0091] Immediate Release Portion Prescription:

[0092] Tipipenem 10%

[0093] Microcrystalline Cellulose 90%

[0094] Hydroxypropyl Cellulose 5%

[0095] Delayed 4 hour partial prescription:

[0096]

[0097] Delayed 8 hours partial prescription:

[0098]

[0099] Preparation method: according to embodiment 1 preparation method.

Embodiment 3

[0100] Embodiment 3 Pulse-type administration preparation of tipipenem microspheres

[0101] prescription:

[0102] Immediate Release Portion Prescription:

[0103] Tipipenem 12%

[0104] Dextrin 85%

[0105] Hydroxypropyl Cellulose 5%

[0106] Delayed 4 hour partial prescription:

[0107]

[0108] Delayed 8 hours partial prescription:

[0109]

[0110] Preparation method: according to embodiment 1 preparation method.

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Abstract

The invention relates to a pulse-type administration preparation of anti-drug-resistant-bacteria antibiotic microsphere, wherein the preparation comprises three parts capable of achieving pulse slow release in three times. The three parts include: a quick release part, which contains a main drug core microsphere; an N-hour delaying part, which contains a main drug core microsphere, an inner-layermixture coating, and an outer-layer enteric polymer coating; and a 2N-hour delaying part, which contains a main drug core microsphere, an inner-layer mixture coating, and an outer-layer enteric polymer coating, wherein N is a natural number in a range of 2-6. The main drug is anti-drug-resistant-bacteria antibiotics, which includes carbapenem antibiotics, aminoglycoside antibiotics, and polypeptide antibiotics. The preparation has a pulse-type administration system that ensures conveying of a single medicine or a medicine association at the same time and a controller of pulse-type administration time for efficiently treating diseases, and has maximum patient compliance and minimum side effect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pulse-type administration preparation of antibiotic microspheres against drug-resistant bacteria. Background technique [0002] Although the antibiotics currently used clinically are constantly being updated, starting from the first generation of penicillins, they have gradually developed to antibiotics commonly used in clinical practice, including β-lactams, aminoglycosides, macrolides, lincomycins, peptides, etc. Classes, quinolones, sulfonamides, antituberculosis drugs, antifungal drugs and other antibiotics. However, the abuse of antibiotics will lead to drug resistance (adaptability to drugs) of bacteria, that is to say, the same pathogenic bacteria may not be able to be cured when they are re-infected with this bacteria after using a certain antibiotic for many times. This disease necessitates the use of stronger antibiotics. In this way, it is possible to allow bacter...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K47/38A61K47/26A61K47/12A61K47/02A61K47/10A61K31/427A61P31/04
Inventor 陈闯葛彦杰于飞宋更申肖佳普
Owner BEIJING YUEKANGKECHUANG PHARM TECH CO LTD
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